Abstract： Objective： To observe the clinical effect of Qingre Lifei Decoction combined with early pulmonary rehabilitation training for acute exacerbation of chronic obstructive pulmonary disease (COPD) in the senile. Methods：A total of 120 cases of senile patients with acute exacerbation of COPD were selected and divided into the treatment group and the control group according to the random number table method， with 60 cases in each group. The control group was treated with routine western medicine， and the treatment group was additionally treated with Qingre Lifei Decoction combined with early pulmonary rehabilitation training based on the treatment of the control group. Both groups were treated for two courses， with 7 days being one course. After treatment， traditional Chinese medicine (TCM) syndrome scores， clinical effects， and levels of lung function [percentage of predicted value of forced expiratory volume in one second (FEV1%)，and ratio of forced expiratory volume in one second to forced vital capacity (FVC)] and inflammatory factors in serum [C- reactive protein (CRP)， interleukin- 6 (IL- 6) and tumor necrosis factor- α (TNF- α)] were evaluated after two- course treatment. Results：The total effective rate was 96.67% in the treatment group and 85.00% in the control group，the difference being significant (P＜ 0.05). Before treatment， there was no significant difference being found in the comparison of TCM syndrome scores between the two groups (P＞0.05)；after treatment，TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and the TCM syndrome score in the treatment group was lower than that in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of levels of FEV1% and FEV1/FVC between the two groups (P＞0.05)；after treatment，levels of FEV1% and FEV1/FVC in the two groups were increased when compared with those before treatment (P＜0.05)， and the levels of FEV1% and FEV1/FVC in the control group were higher than those in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of levels of CRP，IL-6 and TNF-α in serum between the two groups (P＞0.05)；after treatment，levels of CRP，IL- 6 and TNF- α in serum in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above indexes in the treatment group were lower than those in the control group (P＜0.05). Conclusion：Qingre Lifei Decoction combined with early pulmonary rehabilitation training for acute exacerbation of COPD in the senile can relieve clinical symptoms and signs，improve lung function and reduce inflammatory responses in the body.