柴芩温胆汤联合阿普唑仑治疗痰热扰心型原发性失眠合并焦虑临床研究
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R256.23

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中山市社会公益科技研究重大项目(2019B1016)


Clinical Study on Chaiqin Wendan Decoction Combined with Alprazolam for Primary Insomnia Complicated with Anxiety of Phlegm-Heat Harassing the Heart Type
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    摘要:

    目的:观察柴芩温胆汤联合阿普唑仑治疗痰热扰心型原发性失眠合并焦虑的临床疗效。方法:选 取60 例痰热扰心型原发性失眠合并焦虑患者,按随机数字表法分为治疗组和对照组,每组30 例。对照组给予 阿普唑仑治疗,治疗组在对照组基础上给予柴芩温胆汤治疗,2 组均治疗4 周。比较2 组临床疗效,以及治疗 前后匹兹堡睡眠质量指数(PSQI)、焦虑自评量表(SAS)、中医证候评分。结果:治疗后,治疗组总有效率 90.00%,高于对照组60.00%,差异有统计学意义(P<0.05)。2 组PSQI、SAS、中医证候评分均较治疗前降 低,治疗组PSQI、SAS、中医证候评分均低于对照组,差异均有统计学意义(P<0.05)。结论:柴芩温胆汤联 合阿普唑仑治疗痰热扰心型原发性失眠合并焦虑,可有效缓解患者的临床症状及焦虑情绪,改善睡眠质量,疗 效优于单独使用阿普唑仑治疗。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Chaiqin Wendan Decoction combined with Alprazolam on primary insomnia complicated with anxiety of phlegm-heat harassing the heart type. Methods:A total of 60 cases of patients with primary insomnia complicated with anxiety of phlegm- heat harassing the heart type were selected and divided into the treatment group and the control group according to the random number table method, with 30 cases in each group. The control group was treated with Alprazolam,and the treatment group was additionally treated with Chaiqin Wendan Decoction based on the treatment of the control group. Both groups were treated for 4 weeks. The scores of Pittsburgh Sleep Quality Index (PSQI), Self- Rating Anxiety Scale (SAS) and traditional Chinese medicine(TCM) syndrome before and after treatment,as well as clinical effects were compared between the two groups. Results: After treatment,the total effective rate was 90.00% in the treatment group,higher than that of 60.00% in the control group,the difference being significant (P<0.05). The PSQI,SAS and TCM syndrome scores in the two groups were decreased when compared with those before treatment,and the above three scores in the treatment group were lower than those in the control group,differences being significant (P<0.05). Conclusion:In the treatment of primary insomnia complicated with anxiety of phlegm-heat harassing the heart type,Chaiqin Wendan Decoction combined with Alprazolam can effectively relieve clinical symptoms, anxiety,improve sleep quality,and has better curative effects than the simple application of Alprazolam.

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李青,李亮,赖康安,王红,车思锦,覃子祥.柴芩温胆汤联合阿普唑仑治疗痰热扰心型原发性失眠合并焦虑临床研究[J].新中医,2023,55(24):65-69

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  • 在线发布日期: 2023-12-30
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