Abstract： Objective： To study the medication rules of famous doctors in the treatment of chronic obstructive pulmonary disease based on data mining. Methods： The complete medical records for the treatment of chronic obstructive pulmonary disease were collected and sorted out from seven books in the library of Guangzhou University of Chinese Medicine， including Analysis of Medical Records of Famous Doctors of Respiratory Diseases， Record of Differentiation and Treatment of Respiratory Diseases of Famous Chinese Medicine Doctors，and Clinical Cases of Modern Chinese Medicine Doctors (Lung Disease Volume). Data were extracted and the frequency of symptoms，syndromes，and medicines were counted based on the Traditional Chinese Medicine Inheritance Computing Platform V3.0. Association analysis was performed for the core medicine combination (set support level of 17.5%，confidence level of 0.6). The core prescriptions were extracted according to the unsupervised K-means clustering algorithm (set the number of clusters to 3). Results： A total of 44 medical cases and 103 prescriptions， involving 229 medicinals， were included. The top 10 symptoms were cough， wheezing， sputum， chest tightness， edema， shortness of breath，poor appetite，palpitation，shortness of breath，and cyanosis. The top 10 medicinals were Glycyrrhizae Radix et Rhizoma， Armeniacae Semen Amarum， Poria， Pinelliae Rhizoma， Perillae Fructus， Mori Cortex， Platycodonis Radix， Citri Reticulatae Pericarpium， Atractylodis Macrocephalae Rhizoma， and Astragali Radix. The core combinations with high frequency were Glycyrrhizae Radix et Rhizoma- Armeniacae Semen Amarum， Glycyrrhizae Radix et Rhizoma- Poria， Glycyrrhizae Radix et Rhizoma- Pinelliae Rhizoma， etc.； the core medicine was modified Erchen Decoction combined with Dingchuan Decoction. The cluster analysis showed that the three core compositions were Armeniacae Semen Amarum，Poria and Glycyrrhizae Radix et Rhizoma，Pinelliae Rhizoma，Atractylodis Macrocephalae Rhizoma and Glycyrrhizae Radix et Rhizoma， and Astragali Radix， Schisandrae Chinensis Fructus and Glycyrrhizae Radix et Rhizoma. The main treatment methods were resolving phlegm， relieving panting， clearing heat and supplementing qi. Conclusion：In syndrome differentiation and treatment，most famous doctors are based on the pathogenesis of deficiency in the origin and excess in the superficiality，and follow the principle of "In urgent conditions，treat the symtom；in moderate conditions，treat the root". They pay attention to reinforcing healthy qi and consolidating the root，supplementing the qi，and taking into account dispelling phlegm，removing dampness and directing qi downward.