Abstract： Objective： To observe the clinical effect of Qushi Huayu Sanjie Decoction combined with Guizhi Fuling Capsules for uterine fibroids with static accumulation of phlegm-damp syndrome. Methods：A total of 106 patients with uterine fibroids with static accumulation of phlegm- damp syndrome were selected as the research subjects and divided into the combination group and the control group according to the random number table method，with 53 cases in each group. The control group was treated with Guizhi Fuling Capsules，and the combination group was treated with Qushi Huayu Sanjie Decoction on the basis of the treatment of the control group. Both groups were treated for 12 weeks. The clinical effects and adverse reactions were compared between two groups. The levels of sex hormones [estradiol (E2)， follicle stimulating hormone (FSH)， progesterone (P)， and luteinizing hormone (LH)]， hemodynamic indicators [peak systolic blood flow velocity (PSV)， resistance index (RI)， and pulsatile index (PI)]， tumor markers [carbohydrate antigen 125 (CA125)， and human epididymal protein 4 (HE4)]， serum vascular endothelial growth factor (VEGF)， myocardin， nuclear factor- κB p65 (NF- κB p65)， as well as menstrual cycle， uterine and fibroid volume were compared between the two groups before and after treatment. Results： After 12 weeks of treatment，the total effective rate was 92.45% in the combination group，higher than that of 77.36% in the control group (P＜0.05). After treatment，the levels of E2，FSH，P，and LH in serum in the two groups were decreased (P＜0.05)， and the levels in the combination group were lower than those in the control group (P＜0.05). After treatment，the levels of VEGF and NF- κB p65 in serum in the two groups were decreased (P＜0.05)，and the levels of myocardin were increased (P＜0.05)；the levels of VEGF and NF- κB p65 in serum in the combination group were lower than those in the control group (P＜ 0.05)，and the level of myocardin was higher than that in the control group (P＜0.05). After treatment，the uterine and fibroid volume in the two groups were decreased (P＜0.05)， and the menstrual cycle was shortened (P＜0.05)； the uterine and fibroid volume in the combination group was smaller than that in the control group (P＜0.05)，and the menstrual cycle was shorter than that in the control group (P＜0.05). After treatment，the PSV in the two groups were decreased (P＜0.05)，and RI and PI were increased (P＜ 0.05)；the PSV in the combination group was lower than that in the control group (P＜0.05)，and RI and PI were higher than those in the control group (P＜0.05). After treatment the levels of CA125 and HE4 were decreased (P＜0.05)，and the levels in the combination group were lower than those in the control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion：The combination of Qushi Huayu Sanjie Decoction and Guizhi Fuling Capsules has a good curative effect and high safety in treating uterine fibroids with static accumulation of phlegm- damp syndrome，and can significantly improve the levels of sex hormones and hemodynamics in patients，and reduce the risk of cancer.