Abstract： Objective： To observe the clinical study on Wenjing Qiangyao Mixture for lumbar disc herniation of wind-cold obstruction type. Methods：A total of 130 patients with lumbar disc herniation were selected and divided into the trial group and the control group，with 65 cases in each group. The trial group was given Wenjing Qiangyao Mixture for treatment， and the control group was treated with Fengshi Gutong Capsules. The clinical effects and incidence of adverse reactions in both groups were observed；the changes of lumbar pain， including scores of Visual Analogue Scale (VAS) and Japanese Orthopaedic Association (JOA)，traditional Chinese medicine (TCM) syndrome scores，and levels of interleukin-6 (IL-6)， tumor necrosis factor- α (TNF- α) ， superoxide dismutase (SOD) ， nitric oxide (NO) ， cyclooxygenase- 2 (COX-2)， endothelin-1 (ET-1)， prostaglandin E2 (PGE2) and interleukin-1 β (IL-1 β) were compared between the two groups before and after treatment. Results：The total clinical effective rate was 98.46% in the trial group and 80.00% in the control group，the difference being significant (P＜0.05). Three days，ten days and twenty days after treatment， the VAS scores in the two groups were lower than those before treatment，and the JOA scores were higher than those before treatment，the difference being significant (P＜0.05). After treatment， the TCM syndrome scores of heavy pain in the lumbar， cold- induced aggravation， great pain when moving and limited movement in both groups were decreased when compared with those before treatment (P＜0.05)，and the above scores in the trial group were lower than those in the control group (P＜0.05). After treatment，the levels of serum inflammatory factors，including IL- 6，NO and TNF- α in both groups were decreased when compared with those before treatment (P＜ 0.05)，the SOD levels were increased when compared with those before treatment (P＜0.05)；the levels of IL-6，NO and TNF-α in the trial group were lower than those in the control group (P＜0.05)，and the SOD level was higher than that in the control group (P＜0.05). After treatment， the levels of serum pain mediators， including COX- 2， ET- 1， PGE2 and IL- 1β in both groups were decreased when compared with those before treatment (P＜0.05)，and the above levels in the trial group were lower than those in the control group (P＜0.05). There was no obvious adverse reaction in the two groups during treatment. Conclusion： Wenjing Qiangyao Mixture has a good curative effect on lumbar disc herniation， which can effectively reduce the lumbar pain of patients，and improve the lumbar function with good safety.