Abstract：Objective：To observe the clinical effect of nasal feeding with Chaishao Chengqi Decoction combined with raw rhubarb enema for severe acute pancreatitis complicated with enteroparalysis. Methods： A total of 72 cases of patients with severe acute pancreatitis complicated with enteroparalysis were divided into the control group and the treatment group according to the random number table method，with 36 cases in each group. The control group was treated with routine western medicine，and the treatment group was additionally treated with nasal feeding with Chaishao Chengqi Decoction combined with raw rhubarb enema based on the treatment of the control group. Both groups were treated for 7 days. The clinical effects and recovery time of gastrointestinal function were compared between the two groups. Before and after treatment， traditional Chinese medicine (TCM) syndrome scores， and levels of blood calcium， inflammatory indexes and intestinal flora were compared between the two groups. Results： During treatment，2 cases were lost and 34 cases were completed in the control group；2 cases were lost and 34 cases were completed in the treatment group. The total effective rate was 91.18% in the treatment group，higher than that of 70.59% in the control group (P＜0.05). The relief time of abdominal distension and abdominal pain， recovery time of bowel sounds recovering to normal， first spontaneous defecation time， first spontaneous exhaust recovery time， fasting time， and time of intra- abdominal hypertension recovering to normal were all shorter than those in the control group (P＜0.05). After treatment，the TCM syndrome scores，and levels of white blood cell count，C-reactive protein (CRP)，tumor necrosis factor-α (TNF- α)，and interleukin- 6 (IL- 6) in the two groups were decreased when compared with those before treatment (P＜0.05)，and blood calcium levels were increased (P＜0.05). After treatment，TCM syndrome scores，and levels of white blood cell count，CRP，TNF- α and IL-6 were lower than those in the control group (P＜0.05)， and the blood calcium level was higher than that in the control group (P＜0.05). After treatment， the levels of Enterococcus and Escherichia coli in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of Lactobacillus and Bifidobacterium were increased (P＜0.05). After treatment，the levels of Enterococcus and Escherichia coli in the treatment group were lower than those in the control group (P＜0.05)，and the levels of Lactobacillus and Bifidobacterium were higher than those in the control group (P＜0.05). Conclusion： Nasal feeding with Chaishao Chengqi Decoction combined with raw rhubarb enema for severe acute pancreatitis complicated with enteroparalysis can accelerate the recovery of gastrointestinal function， reduce inflammatory responses， improve intestinal flora，and have a significant clinical effect.