Abstract： Objective： To observe the curative effect of Naoxintong Capsules combined with Gingko Ketone Ester Dropping Pills on non-cardiogenic cerebral infarction. Methods：A total of 76 cases of patients with non- cardiogenic cerebral infarction were selected and divided into the control group and the observation group according to different treatment methods， with 38 cases in each group. The control group was treated with Naoxintong Capsules， and the observation group was treated with Naoxintong Capsules combined with Gingko Ketone Ester Dropping Pills. Clinical effects and the incidence of adverse reactions were observed in the two groups. The changes in blood indexes [hematocrit (HCT)， plasma viscosity (PV)， fibrinogen (Fg)， and D- dimer (D- D)]， cerebral hemodynamics indexes [mean blood flow velocity (Vm)，blood flow (Qm)，dynamic resistance (DR)，and peripheral resistance (Rv)]，and the scores of National Institute of Health Stroke Scale (NIHSS) and Activities of Daily Living (ADL) Scale during treatment were compared between the two groups before and after treatment. Results：After 4 weeks of treatment，the total clinical effective rate was 92.11% in the observation group and 71.05% in the control group， the difference being significant (P＜0.05). After 4 weeks of treatment， the incidence of adverse reactions was 18.42% in the observation group and 15.79% in the control group，no significant difference being found in the comparison (P＞0.05). After 4 weeks of treatment，the levels of HCT，PV，Fg，and DD in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above four indexes in the observation group were lower than those in the control group (P＜0.05). After 4 weeks of treatment，Vm and Qm in the two groups were increased when compared with those before treatment (P＜ 0.05)， and DR and Rv were decreased when compared with those before treatment (P＜0.05)； Vm and Qm in the observation group were higher than those in the control group (P＜0.05)，and DR and Rv in the observation group were lower than those in the control group (P＜0.05). After 4 weeks of treatment，NIHSS scores and ADL scores in the two groups were increased when compared with those before treatment (P＜ 0.05)，and the above two scores in the observation group were larger than those in the control group (P＜ 0.05). Conclusion：In the treatment of non-cardiogenic cerebral infarction，Naoxintong Capsules combined with Gingko Ketone Ester Dropping Pills can improve clinical effects and cerebral blood flow， promote neurological recovery，and enhance the quality of prognosis，with high safety.