Abstract：Objective：To observe the application value of hot compress at Shenshu point (BL 23) with Baoshen Adhesive Plaster combined with multi-mode medical health management in treating chronic renal failure (CRF). Methods：A total of 106 cases of CRF patients were retrospectively analyzed and divided into the control group and the combination group according to different treatment methods ， with 49 and 57 cases in each group respectively. The control group was given multi- mode medical health management，and the combination group was additionally treated with hot compress at Shenshu point (BL 23) with Baoshen Adhesive Plaster based on the treatment of the control group. Before and after treatment，quantitative classification scores of CRF symptoms (mental state，facial symptoms，digestive system abnormalities)，Short Form Health Survey (SF- 36) scores，and patients' satisfaction with nursing services， medical quality， hospital environment and management were compared between the two groups. Results： After treatment， the quantitative classification scores of symptoms including mental state，facial symptoms and digestive system abnormalities on the two groups were decreased when compared with those before treatment (P ＜ 0.05) ， and the scores in the combination group were lower than those in the control group (P＜0.05). After treatment， the SF- 36 scores of general health， interpersonal communication， role function and mental health in the two groups were increased when compared with those before treatment (P＜0.05)， and the above scores in the combination group were higher than those in the control group (P＜0.05). After treatment， the satisfaction with nursing service， medical quality， hospital environment and management was 96.49% ， 92.98% ， 91.23% and 94.74% respectively in the combination group and 81.63% ， 75.51% ， 77.55% and 79.59% respectively in the control group，differences being significant (P＜0.05). Conclusion：Hot compress at Shenshu point (BL 23) with Baoshen Adhesive Plaster combined with multi- mode medical health management can effectively relieve the clinical symptoms of CRF patients，improve their quality of life and satisfaction with treatment.