Abstract： Objective： To observe the effect of Yulin Yanzong Decoction combined with estrogenprogesterone sequential therapy for premature ovarian failure of liver depression and kidney deficiency type. Methods： A total of 92 cases of patients with premature ovarian failure of liver depression and kidney deficiency type were selected and divided into the observation group and the control group according to the random number table method， with 46 cases in each group. Both groups were treated with estrogenprogesterone sequential therapy， and the observation group was additionally treated with Yulin Yanzong Decoction. Both groups were treated for three menstrual cycles. Before and after treatment， traditional Chinese medicine (TCM) syndrome scores were assessed； sex hormone indexes [follicle stimulating hormone (FSH)， luteinizing hormone (LH)， estrogen (E2)]， number of antral follicles and endometrial thickness were detected. The incidence of adverse reactions during treatment， the rate of menstruation recovery during 6 months of follow- up and the clinical effects were compared between the two groups. Results：After treatment，the curative effect in the observation group was better than that in the control group (P＜0.05)，and the total effective rate was higher than that in the control group，differences being significant (P＜0.05). TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the TCM syndrome score in the observation group was lower than that in the control group (P＜0.05). The levels of FSH and LH in the two groups were decreased when compared with those before treatment (P＜0.05)， and the levels of E2 were increased when compared with those before treatment (P＜0.05). The levels of FSH and LH in the observation group were lower than those in the control group (P＜0.05)， and the level of E2 in the observation group was higher than that in the control group (P＜0.05). The number of antral follicles and the endometrial thickness in the two groups were increased when compared with those before treatment (P＜0.05)，and the number of antral follicles and the endometrial thickness in the observation group were higher than those in the control group， differences being significant (P＜0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups (P＞0.05). After 6 months of follow-up，the rate of menstruation recovery in the observation group was higher than that in the control group (P＜0.05). Conclusion：The application of Yulin Yanzong Decoction combined with estrogen-progesterone sequential therapy for premature ovarian failure of liver depression and kidney deficiency type can effectively improve the clinical symptoms and ovarian function，regulate endocrine disorders and promote menstruation，with good safety.