Abstract： Objective： To observe the clinical effect of the therapy of modified Xiangsha Yangwei Decoction combined with Teprenone on chronic superficial gastritis (CSG) of spleen- stomach deficiency cold syndrome. Methods： A total of 108 cases of CSG patients with spleen- stomach deficiency cold syndrome were selected and divided into the control group and the study group according to the random number table method，with 54 cases in each group. The control group was given Teprenone for treatment， of which the patients complicated with helicobacter pylori (Hp) infection were additionally treated with triple therapy，and the study group was additionally treated with modified Xiangsha Yangwei Decoction based on the treatment of the control group. Both groups were treated for 4 weeks. The clinical effects，traditional Chinese medicine(TCM) syndrome scores and levels of inflammatory indicators including interleukin- 8 (IL-8)，C-reactive protein (CRP) and monocyte chemotactic protein-1 (MCP-1) were compared between the two groups. The incidence of adverse reactions were recorded. Results： After treatment， the total effective rate was 92.59% in the study group，higher than that of 77.78% in the control group (P＜0.05). The scores of epigastric pain，desire for warmth and pressing，distention and fullness after eating，torpid intake and poor appetite， sloppy stool and mental fatigue and lack of strength in both groups were decreased when compared with those before treatment (P＜0.05)， and the above six TCM syndrome scores in the study group were lower than those in the control group (P＜0.05). The levels of serum IL-8， CRP and MCP- 1 in both groups were decreased when compared with those before treatment (P＜0.05)， and the above three levels in the study group were lower than those in the control group (P＜0.05). During the treatment period， no significant adverse reactions were observed in both groups. Conclusion： The therapy of modified Xiangsha Yangwei Decoction combined with Teprenone can enhance the clinical effect on CSG patients with spleen-stomach deficiency cold syndrome，which can effectively mitigate the clinical symptoms of patients and inhibit the inflammatory responses，with good safety.