Abstract： Objective： To observe the clinical effect of external wash with Kushen Baibu Huangbai Decoction combined with antibiotics for bacterial vaginitis. Methods：A total of 206 cases of patients with bacterial vaginitis were divided into the control group and the treatment group according to the random number table method，with 103 cases in each group. The control group was treated with antibiotics，and the treatment group was treated with Kushen Baibu Huangbai Decoction combined with antibiotics. Both two groups were treated for one months. Traditional Chinese medicine (TCM) syndrome scores， the distribution of vaginal flora types， the levels of inflammatory factors were compared before and after treatment between the two groups. Clinical effects and the incidence of adverse reactions were compared between the two groups. Results：After one month treatment，the total effective rate was 99.03% in the treatment group， higher than that of 92.23% in the control group (P＜0.05). After treatment， the TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜ 0.05)，and the scores in the treatment group were lower than those in the control group (P＜0.05). After treatment，the distribution of Lactobacilli in the two groups was increased (P＜0.05)，and the distribution of Bacteroides， Enterobacter， Candida albicans， and Mycoplasma was decreased (P＜0.05)； the distribution of Lactobacilli in the treatment group was more than that in the control group (P＜0.05)，and the distribution of Bacteroides，Enterobacter，Candida albicans，and Mycoplasma in the treatment group was less than that in the control group (P＜0.05). After treatment，the levels of C-reactive protein (CRP)，tumor necrosis factor- α (TNF- α) and interleukin 6 (IL- 6) in serum in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels in the treatment group were lower than those in the control group (P＜0.05). The incidence of adverse reactions in the treatment group was lower than that in the control group (P＜0.05). There was no significant difference being found in the comparison of the recurrence rates between the two groups(P＞0.05). Conclusion：Kushen Baibu Huangbai Decoction combined with antibiotics for patients with bacterial vaginitis can enhance clinical effects， effectively alleviate symptoms，optimize the distribution of vaginal flora，control inflammatory reactions，and reduce the incidence of adverse drug reactions.