Abstract： Objective： To discuss the clinical effect of the therapy of Naoxintong Capsules combined with Metoprolol on arrhythmia of coronary heart disease and its effect on inflammatory factors. Methods：A total of 96 patients with arrythmia of coronary heart disease were divided into two groups according to the random number table method， with 48 cases in each group. The control group was given Metoprolol for treatment， and the treatment group was treated with Naoxintong Capsules combined with Metoprolol. Before and after treatment，the traditional Chinese medicine (TCM) syndrome scores，and levels of Holter and inflammatory factors were compared between the two groups； the clinical effects and incidence of adverse reactions were analyzed. Results：The total effective rate was 97.92% in the treatment group and 81.25% in the control group， the difference being significant (P＜0.05). After treatment， the TCM syndrome scores of chest pain，chest oppression，palpitation and shortness of breath in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above four scores in the treatment group were lower than those in the control group (P＜0.05). After treatment， the number of ventricular extrasystole and nonsustained ventricular tachycardia in both groups was respectively decreased when compared with those before treatment (P＜0.05)， and the QTc interphase was increased when compared with that before treatment (P＜0.05)； the number of ventricular extrasystole and nonsustained ventricular tachycardia in the treatment group was lower than that in the control group，respectively (P＜ 0.05)， and the QTc interphase was longer than that in the control group (P＜0.05). After treatment， the levels of MCP- 1， hs- CRP and IL- 6 in both groups were decreased when compared with those before treatment，and the above three levels in the treatment group were lower than those in the control group (P＜0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups (P＞0.05). Conclusion：The therapy of Naoxintong Capsules combined with Metoprolol can achieve a good clinical effect on arrhythmia of coronary heart disease， which can improve the clinical symptoms and electrocardiogram indexes，decrease the levels of inflammatory factors and reduce the adverse reactions.