Abstract： Objective： To observe the clinical effect of Modified Dabuxin Decoction combined with western medicine for coronary heart disease complicated with ventricular premature beat. Methods：A total of 90 patients with coronary heart disease complicated with ventricular premature beat were divided into the control group and the trial group according to the random number table method， with 45 cases in each group. The control group was given western medicine treatment， and the trial group was additionally treated with Modified Dabuxin Decoction based on the treatment of the control group. Both groups were treated continuously for 4 weeks. Traditional Chinese medicine (TCM) syndrome scores and levels of angiotensinⅡ(AngⅡ)，creatine kinase-MB (CK-MB)，and N-terminal pro-brain natriuretic peptide (NTproBNP) in serum were compared before and after treatment between the two groups. The numbers of ventricular premature beats，nonsustained ventricular tachycardia and bigeminy of ventricular prematurebeat， and the values of turbulence slope (TS) and turbulence onset (TO) were compared before and after treatment between the two groups. The average energy loss (EL-ave)，left ventricular end systolic volume (LVESV)， left ventricular myocardial mass index (LVMI)， coronary flow reserve (CFR)， index of microvascular resistance (IMR)， resistance peripheral- V (Rp- V)， and mean blood flow (Qmean) were compared before and after treatment between two groups. The clinical effects and incidence of adverse reactions were evaluated in the two groups. Results： The total effective rate was 97.78% in the trial group， higher than that of 82.22% in the control group (P＜0.05). After treatment， Ang II， CK- MB and NT- proBNP in serum， TO values， the number of ventricular premature beats， nonsustained ventricular tachycardia and bigeminy of ventricular prematurebeat，LVMI，LVESV，Rp-V，and TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above indexes in the trial group were lower than those in the control group (P＜0.05). After treatment， the TS values and levels of EL- ave， Qmean， CFR and IMR in the two groups were increased when compared with those before treatment (P＜0.05)，and the TS value and levels of EL-ave，Qmean，CFR and IMR in the trial group were higher than those in the control group (P＜0.05). No adverse reaction occurred in the two groups. Conclusion： Modified Dabuxin Decoction combined with western medicine has a definite therapeutic effect on coronary heart disease complicated with ventricular premature beat， which can reduce the number of ventricular premature beats in patients， improve heart rate turbulence and left ventricular structural remodeling，regulate coronary microcirculation，and have high safety.