Abstract：Objective：To observe the clinical effect of Bumu Yizi Method(Jianpi Qingfei Prescription) on beaded throat obstruction chronic hypertrophic pharyngitis and its effect on the levels of serum inflammatory factors and immunologic factors. Methods： A total of 60 patients with beaded throat obstruction chronic hypertrophic pharyngitis were selected and randomly divided into the treatment group and the control group，with 30 cases in each group. The control group was given Amoxicillin Capsules and Budesonide Suspension for Inhalation for treatment，and the treatment group was additionally treated with Bumu Yizi Method with Chinese medicines based on the treatment of the control group. The two groups were treated for 2 weeks. The clinical effects，traditional Chinese medicine (TCM) syndrome scores，levels of serum inflammatory factors，including interleukin- 1β (IL-1β)，interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α)，and changes of levels of serum immunologic factors，including epidermal growth factor (EGF)， secretory immunoglobulin A (SIgA) and immunoglobulin E (IgE) were compared between the two groups before and after treatment. Results：The total effective rate was 96.67% in the treatment group and 73.33% in the control group， the difference being significant (P＜0.05). Before treatment， there was no significant difference being found in the comparisons of TCM syndrome scores of scorching- hot throat， sore throat and congestion，irritating cough with no phlegm and dry mouth and hoarse voice between the two groups (P＞0.05). After treatment， the above four scores in both groups were decreased when compared with those before treatment (P＜0.05)，and the above four scores in the treatment group were lower than those in the control group (P＜0.05). After treatment，the levels of IL-1β，IL-6 and TNF-α in both groups were decreased when compared with those before treatment (P＜0.05)，and the above three levels in the treatment group were lower than those in the control group (P＜0.05). After treatment， the levels of IgE in both groups were decreased when compared with those before treatment，and the levels of EGF and SIgA were increased when compared with those before treatment (P＜0.05)；the IgE level in the treatment group was lower than that in the control group，and the levels of EGF and SIgA were higher than those in the control group (P＜0.05). Conclusion：Based on the treatment with routine western medicine， the Bumu Yizi Method has a significant curative effect on beaded throat obstruction chronic hypertrophic pharyngitis，which can enable the down-regulation of the levels of serum inflammatory factors，improve the immune function of patients and effectively mitigate the TCM syndrome.