Abstract：Objective：To observe the clinical effect of Qingre Lishi Huayu Prescription for sequelae of pelvic inflammatory disease of retention of damp- heat type， and its effect on pelvic blood stasis microenvironment，and toll- like receptor 4 (TLR4)，SMAD homologue 3 (Smad3) and soluble apoptosisrelated factors (sFAS) in serum. Methods： A total of 126 patients with sequelae of pelvic inflammatory disease who met the inclusion criteria were selected and randomly divided into two groups according to the random number table method， with 63 cases in each group. The control group was treated with routine western medicine，and the observation group was treated with Qingre Lishi Huayu Prescription based on routine western medicine. Both groups were treated continuously for four weeks. In the two groups， sFas， TLR4， and levels of tumor necrosis factor- α (TNF- α)， high mobility group protein 1 (HMGB1)， Smad3，and transforming growth factor-β1 (TGF- β1) in serum were observed before and after treatment. The maximum blood flow velocity (Vmax)， resistance index (RI)， and pulsation index (PI) of the uterine artery were detected. The diameter of inflammatory masses and the maximum depth of pelvic fluid accumulation were measured. The traditional Chinese medicine (TCM) syndrome scores and pain in Visual Analogue Scale (VAS) scores were evaluated in the two groups. The clinical effects were compared between the two groups. Results：After treatment，sFas，TLR4，TNF- α，HMGB1，Smad3，TGF- β1， RI and PI in the two groups were decreased when compared with those before treatment，and the above indexes in the observation group were lower than those in the control group，differences being significant (P＜0.05). After treatment， Vmax in both groups were increased when compared with those before treatment，and the one in the observation group was higher than that in the control group，the difference being significant (P＜0.05). After treatment， the diameters of inflammatory masses， maximum depth of pelvic fluid accumulation， TCM syndrome scores， and pain in VAS scores in the two groups were decreased when compared with those before treatment， and the indexes in the observation group were lower than those in the control group，differences being significant (P＜0.05). The total effective rate was 96.83% in the observation group and 88.89% in the control group， the difference being significant (P＜ 0.05). Conclusion： The Qingre Lishi Huayu Prescription can reduce levels of sFas， TLR4， TNF- α， HMGB1，Smad3 and TGF- β1 in patients with sequelae of pelvic inflammatory disease of retention of damp- heat type， suppress the inflammatory state of the body， improve hemodynamics， pelvic blood stasis microenvironment， pelvic fluid accumulation and inflammatory masses， alleviate clinical symptoms，and enhance clinical effects.