Abstract： Objective： To observe the curative effect of oral administration of Liqi Huatan Xiaoying Decoction combined with external application of Ruyi Jinhuang Powder based on health guidance of daily life for benign thyroid nodules of qi constraint and phlegm obstruction type. Methods： A total of 86 cases of patients with benign thyroid nodules of qi constraint and phlegm obstruction type were selected as the study subjects ， and were randomly divided into the observation group and the control group ， wit 43 cases in each group. Both groups received health guidance of daily life，and the observation group was additionally treated with oral administration of Liqi Huatan Xiaoying Decoction combined with external application of Ruyi Jinhuang Powder. Both groups were treated for three courses of treatment ， with 4 weeks being one course. Before treatment and after three courses of treatment， the scores of main symptoms and Hamilton Anxiety Scale (HAMA) were evaluated， and thyroid function indexes [thyroidstimulating hormone (TSH)， free triiodothyronine (FT3) and free tetraiodothyronine (FT4)]， thyroid autoimmune antibodies [thyroid globular albumin antibody (TgAb)，anti- thyroid peroxidase antibody (Anti- TPO)]， and the diameter of the largest nodule were detected. The curative effects of traditional Chinese medicine (TCM) syndromes and ultrasound were compared between the two groups. The occurrence of adverse reactions were observed during treatment. Results： After treatment， the total effective rate of TCM syndromes in the observation group was higher than that in the control group (P＜0.05). There was no significant difference being found in the comparison of total effective rates of ultrasound therapy between the two groups (P＞0.05). The scores of goiter in the anterior neck，neck swelling sensation，chest scurry pain，and throat discomfort in the two groups were decreased when compared with those before treatment (P＜0.05)， and the four symptom scores in the observation group were lower than those in the control group (P＜0.05). There were no significant differences being found in the comparison of levels of TSH， FT3， FT4， TgAb， and Anti- TPO between the two groups before and after treatment (P＞0.05)； there were no significant differences being found in the comparison of values of the above five indexes between the two groups (P＞0.05). The diameters of the largest nodules in the two groups were decreased when compared with those before treatment，and the HAMA scores were decreased when compared with those before treatment， differences being significant (P＜0.05). The diameter of the largest nodule in the observation group was smaller than that in the control group，and the HAMA score was lower than that in the control group，differences being significant (P＜0.05). No serious adverse reactions occurred during the treatment period in the two groups， and there was no significant abnormality in the function of liver and kidney. Conclusion：Based on health guidance of daily life，the combination of oral administration of Liqi Huatan Xiaoying Decoction and external application of Ruyi Jinhuang Powder for benign thyroid nodules of qi constraint and phlegm obstruction type has good curative effects and safety，which is helpful to improve the main symptoms，eliminate nodules and relieve anxiety of patients.