Abstract：Objective：To study the medication rules of Chinese medicine for non- alcoholic fatty liver disease (NAFLD) based on real world data mining. Methods：The care information of outpatients with NAFLD diagnosed by the Hospital Information System of Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine from January 2019 to July 2022 was collected， and an Excel database was established. With the software Excel 2017，the four natures，five flavors，channel entries and effects of all Chinese medicines were entered. R Statistical Software was used to describe the results and analyze the data. Apriori algorithm of arules package was used to analyze the association rules of prescriptions. Results ： A total of 140 prescriptions were included in this study after screening 1 073 prescriptions collected from 445 patients ， which involved 265 Chinese medicinals ； the top 5 Chinese medicinals in frequency were Bupleuri Radix，Poria，Scutellariae Radix，Curcumae Radix and Salviae Miltiorrhizae Radix et Rhizoma； the top 5 types of Chinese medicinals in frequency were for supplementing deficiency， promoting urination and percolating dampness， clearing heat， invigorating blood and dissolving stasis and rectifying qi； among 15 high- frequency Chinese medicinals， they were mainly bitter， sweet and acrid in flavor， and mainly warm， mild and slightly cold in nature with main channel entries to the liver， spleen， lung and stomach. According to the association rule analysis， the medicinal combinations with the highest degree of support were Bupleuri Radix- Curcumae Radix， and Poria-Atractylodis Macrocephalae Rhizoma；the top 3 medicinal combinations in the degree of confidence were Hyperici Japonici Herba-Ardisiae Japonicae Herba，Aurantii Fructus-Bupleuri Radix，and Curcumae Rhizoma-Aurantii Fructus. The Chinese medicinals were divided into 5 types by the cluster analysis：Type 1 included Aurantii Fructus， Polygoni Cuspidati Rhizoma， Cortex Magnoliae Officinalis， Rhei Radix et Rhizoma，Schisandrae Chinensis Fructus，Sedi Herba，Curcumae Radix，Paeoniae Rubra Radix，Aurantii Fructus， Curcumae Rhizoma， Aucklandiae Radix， Glechomae Herba， Ardisiae Japonicae Herba and Hyperici Japonici Herba；Type 2 included Poria and Atractylodis Macrocephalae Rhizoma；Type 3 included Angelicae Sinensis Radix， Glycyrrhizae Radix et Rhizoma， Paeoniae Radix Alba， Scutellariae Radix and Artemisiae Scopariae Herba；Type 4 included Salviae Miltiorrhizae Radix et Rhizoma and Crataegi Fructus； Type 5 included Astragali Radix， Pinelliae Rhizoma and Citri Reticulatae Pericarpium. Conclusion： The treatment of NAFLD usually adopts liver- soothing and spleen- fortifying ， dampness- dispelling and phlegm-dissolving ， blood-invigorating and stasis-dissolving ， and heat-clearing and toxins-resolving Chinese medicines and they are mostly warm， mild and slightly cold in nature， which enables the dispelling of dampness not to damage yin，and the invigoration of blood not to consume blood. Thus，they work together to play a role in dissolving phlegm，dissipating stasis and discharging turbidity.