Abstract： Objective： To explore the medication rules of Professor XIAO Chun in treating sleepless based on Traditional Chinese Medicine Inheritance Computing Platform (V3.0). Methods：Medical records of sleepless patients treated in Professor XIAO Chun Outpatient Department from January 2015 to February 2021 were collected. Relying on the Traditional Chinese Medicine Inheritance Computing Platform (V3.0)， medication rules and K-means clustering algorithm were used to statistically analyze the frequency of herbal use，four natures，five flavors，channel entry and herbal combination. Results：A total of 590 prescriptions were included，and 163 Chinese herbs were used，and the total frequency of herbs was 11 403 times. In terms of four natures， the top 3 were warm， mild and cold. In terms of five flavors， the top 3 were sweet， acrid and bitter. In terms of channel entry， the top 2 were the spleen channel and the heart channel. Among the 26 high- frequency herbs， the top 10 were Codonopsis Radix， Angelicae Sinensis Radix， Coptidis Rhizoma， Ziziphi Spinosae Semen， Cinnamomi Ramulus， Zingiberis Rhizoma， Jujubae Fructus， Aconiti Lateralis Radix Praeparata， Atractylodis Macrocephalae Rhizoma and Asari Radix et Rhizoma. In terms of herbal combination， the top 3 were Codonopsis Radix- Angelicae Sinensis Radix， Codonopsis Radix-Coptidis Rhizoma，and Angelicae Sinensis Radix-Coptidis Rhizoma. Through association rule analysis， 29 high- frequency herbal combinations and 29 core association rules of herbs were obtained，and 3 core combinations were further extracted. Conclusion：In the syndrome differentiation and treatment of sleepless， Professor XIAO Chun's treatment principle is to harmonize yin and yang， supplemented by the main treatment of boosting qi and calming mind， warming yang and clearing heart heat，and invigorating blood and nourishing blood.