Abstract： Objective： To observe the clinical effect of meridian- point external counter- pulsation on heart failure with preserved ejection fraction. Methods： A total of 72 patients with heart failure with preserved ejection fraction were selected and divided into the control group and the trial group according to the random number table method ， with 36 cases in each group. During the treatment ， 4 cases were dropped off in the control group and 5 cases in the trial group. The control group was given the standard treatment in western medicine， and the trial group was additionally treated with meridian- point external counter-pulsation based on the treatment of the control group. Before and after treatment，the traditional Chinese medicine syndrome (TCM) scores and the levels of N terminal pro B type natriuretic peptide (NTpro BNP) were compared between the two groups； the index of contractility(ICON)，cardiac output (CO) and cardiac index (CI) in both groups were detected. Results：After treatment，the TCM syndrome scores in the two groups were decreased when compared with those before treatment (P＜0.05)， and the TCM syndrome scores in the trial group was lower than that in the control group (P＜0.05). After treatment，the NT-pro BNP levels in both groups were decreased when compared with those before treatment (P＜0.05)； the NT-pro BNP level in the trial group was lower than that in the control group (P＜0.05). After treatment， the ICON， CO and CI in both groups were increased when compared with those before treatment (P＜ 0.05)； the ICON， CO and CI in the trial group were higher than those in the control group (P＜0.05). Conclusion：The meridian-point external counter-pulsation can improve the clinical symptoms of patients with heart failure with preserved ejection fraction， reduce the NT- pro BNP level and enhance the myocardial contraction function.