Abstract：Objective：To observe the clinical effect of acupuncture combined with Butylphthalide and Sodium Chloride Injection for aphasia after cerebral infarction. Methods：A total of 66 cases of patients with aphasia after cerebral infarction were divided into the control group and the observation group according to the random number table method， with 33 cases in each group. Both groups were treated with routine treatment. The control group was treated with intravenous injection of Butylphthalide and Sodium Chloride Injection，and the observation group was additionally treated with acupuncture based on the treatment of the control group. Clinical effects were evaluated in the two groups. Traditional Chinese medicine (TCM) syndrome scores， degree of neurological impairment， language function， and severity of aphasia were compared before and after treatment between the two groups. Results： The total effective rate was 93.94% in the observation group， higher than that of 75.76% in the control group (P＜0.05). After treatment，TCM syndrome scores and National Institute of Health stroke scale (NIHSS) scores in the two groups were decreased when compared with those before treatment (P＜0.05)；the TCM syndrome scores and NIHSS scores in the observation group were lower than those in the control group (P＜0.05). After treatment， the scores of spontaneous speech， listening comprehension， naming， and repetition in the two groups were increased when compared with those before treatment (P＜0.05)，and each score in the observation group was higher than that in the control group (P＜0.05). After treatment， the grading by Boston Diagnostic Aphasia Examination (BDAE) in the two groups was significantly improved when compared with that before treatment (P＜0.05)，and the improvement in the observation group was better than that in the control group (P＜0.05). Conclusion： Acupuncture combined with Butylphthalide and Sodium Chloride Injection has a good curative effect in the treatment of aphasia after cerebral infarction， which can relieve clinical symptoms， improve language function， and reduce the degree of neurological impairment and severity of aphasia.