Abstract： Objective： To observe the clinical effect of the therapy of Wenshen Liniao Prescription combined with electropuncture on neurogenic bladder urinary retention after spinal cord injury. Methods：A total of 130 patients with neurogenic bladder urinary retention after spinal cord injury were selected and divided into the control group and the observation group according to the random number table method， with 65 cases in each group. The control group was given routine treatment in western medicine，and the observation group was additionally treated with Wenshen Liniao Prescription combined with electropuncture based on the treatment of the control group. The clinical effects in the two groups were evaluated； the changes of levels of serum neurotrophic factors and inflammatory factors， average daily single urination volume， maximum urinary flow rate， maximum bladder volume， residual urine volume， traditional Chinese medicine (TCM) syndrome scores and scores of quality of life before and after treatment were compared between the two groups. Results： The total effective rate was 95.38% in the observation group， higher than that of 81.54% in the control group (P＜0.05). After treatment， the levels of serum brain- derived neurotrophic factors (BDNF) in the two groups were increased when compared with those before treatment， the levels of neuron- specific enolase (NSE)， high mobility group box- 1 protein (HMGB1)， interleukin- 1β (IL- 1β) and interleukin- 6 were decreased when compared with those before treatment (P＜0.05)； the serum BDNF level in the observation group was higher than that in the control group，and the levels of NSE，HMGB1，IL-6 and IL-1β were lower than those in the control group (P＜ 0.05). After treatment， the maximum urinary flow rate， average daily single urination volume and maximum bladder volume in the two groups were increased when compared with those before treatment (P＜0.05)；the above three items in the observation group were higher than those in the control group (P＜ 0.05). After treatment，the residual urine volume in both groups was decreased when compared with that before treatment (P＜0.05)，and the residual urine volume in the observation group was lower than that in the control group (P＜0.05). After treatment，the scores of 36-Item Short-Form (SF-36) in the two groups were increased when compared with those before treatment (P＜0.05)， and the TCM syndrome scores were decreased when compared with those before treatment (P＜0.05)； the SF- 36 score in the observation group was higher than that in the control group，and the TCM syndrome score was lower than that in the control group (P＜0.05). Conclusion：The therapy of Wenshen Liniao Prescription combined with electropuncture for neurogenic bladder urinary retention after spinal cord injury can help mitigate the inflammatory responses， improve the neuromechanism and urinary function， and enhance the clinical effect.