Abstract：Objective：To observe the curative effect of Shugan Yiqi Xiaozhi Prescription combined with Polyene Phosphatidylcholine Capsules for non-alcoholic fatty liver disease (NAFLD). Methods： A total of 83 cases of NAFLD patients were selected and divided into the treatment group and the control group according to the random number table method， with 43 and 40 cases in each group respectively. The control group was treated with Polyene Phosphatidylcholine Capsules， and the treatment group was additionally treated with Shugan Yiqi Xiaozhi Prescription based on the treatment of the control group. After two courses of treatment， the clinical effects and curative effect of liver B ultrasonic examination were observed in the two groups. Before and after treatment，the changes in symptom scores of liver constraint and spleen deficiency syndrome，body mass index (BMI)，waist circumference，alanine aminotransferase (ALT)， γ- glutamyl transferase (GGT)， aspartate aminotransferase (AST)， total cholesterol (TC) and triglyceride (TG) were compared between the two groups. Results：After treatment，the symptom scores of liver constraint and spleen deficiency syndrome in the two groups were decreased when compared with those before treatment (P＜0.05)， and the symptom score of liver constraint and spleen deficiency syndrome in the treatment group was lower than that in the control group (P＜0.05). The total clinical effective rate was 93.02% in the treatment group and 75.00% in the control group，the difference being significant (P＜0.05). The total effective rate of liver B ultrasonic examination was 90.70% in the treatment group and 70.00% in the control group， the difference being significant (P＜0.05). After treatment， BMI and waist circumference in the two groups were decreased when compared with those before treatment (P＜0.05)，and BMI and waist circumference in the treatment group were lower than those in the control group (P＜0.05). After treatment， the levels of ALT， GGT， AST， TC and TG in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above five levels in the treatment group were lower than those in the control group (P＜0.05). Conclusion： Shugan Yiqi Xiaozhi Prescription combined with Polyene Phosphatidylcholine Capsules is effective in treating NAFLD， which can effectively reduce the clinical symptoms， regulate BMI and waist circumference， improve liver function and blood lipid indexes，and then improve the prognosis.