益气化瘀醒脑开窍汤联合常规西医治疗气虚血瘀证出血性脑卒中恢复期临床研究
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R743.3

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河南省中医药传承与创新人才工程(仲景工程) 中医药青苗人才项目(豫卫中医函〔2021〕16号)


Clinical Study on Yiqi Huayu Xingnao Kaiqiao Decoction Combined with Routine Western Medicine for Hemorrhagic Stroke with Qi Deficiency and Blood Stasis Syndrome During Convalescence
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    摘要:

    目的:观察益气化瘀醒脑开窍汤联合常规西医治疗气虚血瘀证出血性脑卒中恢复期的临床疗效。 方法:选取136 例气虚血瘀证出血性脑卒中恢复期患者,按随机数字表法分为联合组和对照组各68 例。对照 组采用常规西医治疗,联合组采用益气化瘀醒脑开窍汤联合常规西医治疗,均治疗1 个月。比较2 组治疗前后 美国国立卫生研究院卒中量表(NIHSS) 评分、中医证候积分、改良Barthel 指数(MBI) 评分、血液流变学指 标(全血黏度、血浆黏度) 及血清超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α (TNF-α)、同型半胱氨 酸(Hcy) 水平,比较2 组临床疗效及不良反应。结果:治疗后,2 组NIHSS 评分、中医证候积分均下 降(P<0.05),MBI 评分均升高(P<0.05),且联合组NIHSS 评分、中医证候积分低于对照组(P<0.05), MBI 评分高于对照组(P<0.05)。治疗后,2 组全血高切黏度、低切黏度、血浆黏度均降低(P<0.05),且联 合组低于对照组(P<0.05)。治疗后2 组血清hs-CRP、TNF-α、Hcy 水平均降低(P<0.05),且联合组低于对照 组(P<0.05)。联合组总有效率92.65%,高于对照组80.88%(P<0.05)。2 组不良反应发生率比较,差异无统计 学意义(P>0.05)。结论:益气化瘀醒脑开窍汤联合常规西医治疗气虚血瘀证出血性脑卒中恢复期患者能改善 其神经功能,提高日常生活能力,改善血液流变学,降低炎症因子水平,疗效显著,且用药安全性良好。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Yiqi Huayu Xingnao Kaiqiao Decoction combined with routine western medicine for hemorrhagic stroke with qi deficiency and blood stasis syndrome during convalescence. Methods:A total of 136 cases of patients with hemorrhagic stroke with qi deficiency and blood stasis syndrome during convalescence were selected and divided into the combination group and the control group according to the random number table method, with 68 cases in each group. The control group was treated with routine western medicine,and the combination group was treated with Yiqi Huayu Xingnao Kaiqiao Decoction combined with routine western medicine. Both groups were treated for one month. Before and after treatment, National Institute of Health Stroke Scale (NIHSS) scores,traditional Chinese medicine syndrome scores,Modified Barthel Index (MBI) scores,hemorheology indexes including whole blood viscosity and plasma viscosity, and levels of high- sensitivity C- reactive protein (hs- CRP), tumor necrosis factor- α (TNF- α), and homocysteine (Hcy) in serum were compared between the two groups. The clinical effects and adverse reactions were compared between the two groups. Results:After treatment, the NIHSS scores and traditional Chinese medicine syndrome scores in the two groups were decreased (P<0.05), and the MBI scores were increased (P<0.05); the NIHSS score and traditional Chinese medicine syndrome score in the combination group were lower than those in the control group (P< 0.05),and the MBI score was higher than that in the control group (P<0.05). After treatment,the whole blood high shear viscosity, low shear viscosity, and plasma viscosity in the two groups were decreased (P<0.05),and the indexes in the combination group were lower than those in the control group (P<0.05). After treatment,the levels of hs- CRP and TNF- α and Hcy in serum were decreased (P<0.05),and the levels in the combination group were lower than those in the control group (P<0.05). The total effective rate was 92.65% in the combination group, higher than that of 80.88% in the control group (P<0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups (P>0.05). Conclusion: Yiqi Huayu Xingnao Kaiqiao Decoction combined with routine western medicine for patients with hemorrhagic stroke with qi deficiency and blood stasis syndrome during convalescence can improve their neurological function, abilities of daily living, and hemorheology, and reduce the levels of inflammatory factors,which has significant curative effect and good medication safety.

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关荣杓,尚官红,常丹阳,常晓.益气化瘀醒脑开窍汤联合常规西医治疗气虚血瘀证出血性脑卒中恢复期临床研究[J].新中医,2023,55(19):63-68

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  • 在线发布日期: 2023-10-17
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