Clinical Study on Yiqi Huayu Xingnao Kaiqiao Decoction Combined with Routine Western Medicine for Hemorrhagic Stroke with Qi Deficiency and Blood Stasis Syndrome During Convalescence
Abstract:Objective:To observe the clinical effect of Yiqi Huayu Xingnao Kaiqiao Decoction combined with routine western medicine for hemorrhagic stroke with qi deficiency and blood stasis syndrome during convalescence. Methods:A total of 136 cases of patients with hemorrhagic stroke with qi deficiency and blood stasis syndrome during convalescence were selected and divided into the combination group and the control group according to the random number table method, with 68 cases in each group. The control group was treated with routine western medicine,and the combination group was treated with Yiqi Huayu Xingnao Kaiqiao Decoction combined with routine western medicine. Both groups were treated for one month. Before and after treatment, National Institute of Health Stroke Scale (NIHSS) scores,traditional Chinese medicine syndrome scores,Modified Barthel Index (MBI) scores,hemorheology indexes including whole blood viscosity and plasma viscosity, and levels of high- sensitivity C- reactive protein (hs- CRP), tumor necrosis factor- α (TNF- α), and homocysteine (Hcy) in serum were compared between the two groups. The clinical effects and adverse reactions were compared between the two groups. Results:After treatment, the NIHSS scores and traditional Chinese medicine syndrome scores in the two groups were decreased (P<0.05), and the MBI scores were increased (P<0.05); the NIHSS score and traditional Chinese medicine syndrome score in the combination group were lower than those in the control group (P< 0.05),and the MBI score was higher than that in the control group (P<0.05). After treatment,the whole blood high shear viscosity, low shear viscosity, and plasma viscosity in the two groups were decreased (P<0.05),and the indexes in the combination group were lower than those in the control group (P<0.05). After treatment,the levels of hs- CRP and TNF- α and Hcy in serum were decreased (P<0.05),and the levels in the combination group were lower than those in the control group (P<0.05). The total effective rate was 92.65% in the combination group, higher than that of 80.88% in the control group (P<0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups (P>0.05). Conclusion: Yiqi Huayu Xingnao Kaiqiao Decoction combined with routine western medicine for patients with hemorrhagic stroke with qi deficiency and blood stasis syndrome during convalescence can improve their neurological function, abilities of daily living, and hemorheology, and reduce the levels of inflammatory factors,which has significant curative effect and good medication safety.