Abstract： Objective： To observe the clinical effect of the therapy of Xingshen Tiaoxing acupuncture method combined with routine therapy on post- stroke spasticity. Methods： A total of 106 patients with post-stroke spasticity with syndrome of qi deficiency with blood stasis were included and randomly divided into the observation group and the control group，with 53 cases in each group. The two groups were given basic treatment for controlling blood pressure and blood sugar，regulating blood fat and preventing platelet aggregation， and intervention of rehabilitation plan in convulsion period， and the observation group was additionally treated with Xingshen Tiaoxing acupuncture method. The two groups were given intervention for 4 weeks. The clinical effects were compared between the two groups；the traditional Chinese medicine syndrome scores， spasticity of upper and lower limbs， including scores of Modified Ashworth Scale (MAS)，motor function of limbs，including scores of simplified Fugl-Meyer Assessment Scale (FMA) and activity of daily living， including scores of Modified Barthel Index (MBI) were evaluated before and after treatment； the root mean square (RMS) of surface electromyography of bicipital muscle of arm and quadriceps， indexes of cardiovascular blood flow velocity， including middle cerebral artery (MCA)， posterior cerebral artery (PCA)，vertebral artery (VA)，anterior cerebral artery (ACA) and basilar artery (BA)， and indexes of vasoactive substances，including endothelin-1 (ET-1)，6-ketone-prostaglondin F1α (6-KPGF1α)， thromboxane B2 (TXB2) and nitric oxide (NO) were detected. Results： After treatment， the total effective rate was 88.68% in the observation group，and 69.81% in the control group，the difference being significant (P＜0.05). The scores of hemiplegia，deviated mouth and tongue，sluggish speech，numbness of limbs，headache，dizziness and dizzy vision，limb shaking and eyeball vibrating and the total scores in the two groups were decreased when compared with those before treatment，differences being significant (P＜0.05). The above eight scores and total score in the observation group were lower than those in the control group， differences being significant (P＜0.05). The spasticity of upper and lower limbs in both groups were improved when compared with those before treatment， differences being significant (P＜ 0.05). The improvements of spasticity of upper and lower limbs in the observation group were better than those in the control group，differences being significant (P＜0.05). The scores of FMA and MBI in the two groups were increased when compared with those before treatment， differences being significant (P＜ 0.05). The scores of FMA and MBI in the observation group were higher than those in the control group (P＜ 0.05). The RMS values of surface electromyography of bicipital muscle of arm and quadriceps in the two groups were decreased when compared with those before treatment， differences being significant (P＜ 0.05). The RMS values of surface electromyography of bicipital muscle of arm and quadriceps in the observation group were lower than those in the control group，differences being significant (P＜0.05). The MCA， PCA， ACA， BA and VA in the two groups were increased when compared with those before treatment，differences being significant (P＜0.05). The MCA，PCA，ACA，BA and VA in the observation group were faster than those in the control group， differences being significant (P＜0.05). The levels of serum ET- 1 and TXB2 in both groups were decreased when compared with those before treatment，and the levels of serum NO and 6- K- PGF1α were increased when compared with those before treatment， differences being significant (P＜0.05). The levels of serum ET- 1 and TXB2 in the observation group were lower than those in the control group，and the levels of serum NO and 6-K-PGF1α were higher than those in the control group， differences being significant (P＜0.05). Conclusion： Based on routine therapy and rehabilitation plan， the application of Xingshen Tiaoxing acupuncture method can effectively mitigate the post-stroke spasticity of affected limbs，improve the motor function and activity of daily living of affected limbs，promote the cardiovascular blood flow velocity and enhance the blood circulation of the brain.