Abstract： Objective： To study the effect of Fugui Guanshitong Granules on survival rates， T lymphocytes and tumor markers related to esophageal cancer in patients with advanced esophageal cancer of spleen-kidney yang deficiency and lingering phlegm and obstinate blood type in 42 days after treatment. Methods：A total of 120 cases of patients from nine centers were included and divided into the trial group 1，the trial group 2 and the control group according to the block randomization method，with 40 cases in each group. The trial group 1 was treated with Fugui Guanshitong Granules and Dingxiang Guanshitong Hanhua Pills；the trial group 2 was treated with Dingxiang Guanshitong Hanhua Pills；the control group was treated with Danggui Buxue Decoction and Guizhi Renshen Decoction Granules. All the groups were treated for 42 days. The survival rates，T lymphocytes (CD3 +，CD4 +，CD8 + )，carcinoembryonic antigen (CEA)， and squamous cell carcinoma antigen (SCCA) in the three groups were compared after 42 days of treatment，and the safety was evaluated. Results：The survival rate was 88.6% in the trial group 1，86.8% in the trial group 2，and 72.2% in the control group，there was no significant difference among the three goups (P＞0.05). After treatment， the differences of CD4 + ， CD8 + ， and CEA in the three groups were significant in time (P＜0.05)， but there was no significant difference in the comparison among the three groups (P＞0.05). There was no significant difference in CD3 + and SCCA among the three groups or the comparison of time (P＞0.05). Conclusion： Fugui Guanshitong Granules for patients with advanced esophageal cancer can improve their survival rates and immune function.