Abstract：Objective：To observe the clinical effect of modified Huangqi Jianzhong Decoction combined with chemotherapy for stomach cancer in stage Ⅲb to Ⅳ of the spleen-stomach deficiency-cold type and its effects on the levels of tumor markers [carcinoembryonic antigen (CEA)， carbohydrate antigen 199 (CA199)，carbohydrate antigen 724 (CA724)]，vascular endothelial growth factor (VEGF)，and interleukin-6 (IL- 6). Methods： A total of 82 cases of patients with stomach cancer in stage Ⅲb to Ⅳ of the spleenstomach deficiency- cold type were selected and divided into the observation group and the control group according to their hospital admission sequence (odd or even numbers)，with 41 cases in each group. The control group was treated with chemotherapy with Oxaliplatin combined with 5- Fluorouracil， and the observation group was additionally treated with modified Huangqi Jianzhong Decoction based on the treatment of the control group. Both groups were treated for 2 treatment courses， with 3 weeks being 1 course. Clinical effects，quality of life，the levels of CEA，CA199，CA724，VEGF，IL-6，CD4+，CD8+， CD4 +/CD8 + ratio， and the incidence of adverse reactions were compared between the two groups. Results：After treatment，the total clinical effective rate was 82.93% in the observation group，higher than that of 58.54% in the control group (P＜0.05). The levels of CEA， CA199， CA724， VEGF， and IL- 6 in serum in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of CEA，CA199，CA724，VEGF，and IL- 6 in the observation group were lower than those in the control group (P＜0.05). The levels of CD4+ and CD4+/CD8+ ratio in serum in the two groups were decreased when compared with those before treatment (P＜0.05)， and the levels of CD8 + were increased when compared with those before treatment (P＜0.05)；the levels of CD4+ and CD4+/CD8+ ratio in serum in the observation group were higher than those in the control group (P＜0.05)，and the level of CD8+ in serum in the observation group was lower than that in the control group (P＜0.05). The improvement rate of quality of life was 75.61% in the observation group，higher than that of 48.78% in the control group (P＜0.05). During the treatment，the incidence of gastrointestinal reactions，neutropenia，and peripheral neurotoxicity in the observation group were lower than those in the control group (P＜0.05). Conclusion： Modified Huangqi Jianzhong Decoction combined with chemotherapy for stomach cancer in stage Ⅲb to Ⅳ of the spleenstomach deficiency- cold type can reduce the levels of tumor markers， VEGF， and IL- 6， improve the immune function and quality of life of patients，and alleviate adverse reactions.