Abstract： Objective： To observe the clinical effect of Shengxuebao Mixture combined with recombinant human erythropoietin (rhEPO) for multiple myeloma complicated with anemia. Methods： A total of 88 cases of patients with multiple myeloma complicated with anemia were selected and divided into the observation group and the control group according to the random number table method，with 44 cases in each group. Both groups were given conventional treatment and nursing intervention；the control group was additionally treated with hypodermic injection of rhEPO， and the observation group was additionally treated with Shengxuebao Mixture based on the treatment of the control group. Both groups were treated for 8 weeks. Traditional Chinese medicine (TCM) syndrome scores，blood routine indexes [hemoglobin (Hb)， reticulocyte (RET%)，red blood cell count (RBC)，white blood cell count (WBC)，and blood platelet count (BPC)] before and after treatment，clinical effects，and the incidence of adverse reactions during treatment were compared between the two groups. Results： After treatment， the total clinical effective rate was 93.18% in the observation group，higher than that of 81.82% in the control group (P＜0.05). The scores of white complexion， dizziness and tinnitus， soreness and weakness in the lumbar and knee， and palpitations and shortness of breath in the two groups were decreased when compared with those before treatment (P＜0.05)，and the scores of white complexion，dizziness and tinnitus，soreness and weakness in the lumbar and knee，and palpitations and shortness of breath in the observation group were lower than those in the control group (P＜0.05). The levels of Hb，RET%，RBC，WBC，and BPC in the two groups were increased when compared with those before treatment (P＜0.05)， and the levels of Hb， RET% ， RBC，WBC，and BPC in the observation group were higher than those in the control group (P＜0.05). The incidence of adverse reactions was 15.91% in the observation group and 11.36% in the control group， there being no significance in the difference (P＞0.05). Conclusion：Shengxuebao Mixture combined with rhEPO has a definite curative effect in the treatment of multiple myeloma complicated with anemia and can effectively alleviate clinical symptoms and improve anemia state，with good safety.