Abstract:Objective:To observe the clinical effect of therapy of modified Tiaojing Kangshuai Decoction combined with western medicine on hypovarianism of kidney deficiency and blood stasis type. Methods:A total of 120 patients with hypovarianism of kidney deficiency and blood stasis type were selected and divided into the control group A,the control group B and the observation group according to the random number table method, with 40 cases in each group. The control group A was given western medicine, including Estradiol Valerate Tablets and Progesterone Capsules; the control group B was given modified Tiaojing Kangshuai Decoction,and the observation group was treated with the therapy of modified Tiaojing Kangshuai Decoction combined with western medicine. The three groups were treated for 3 menstrual cycles. The clinical effects, Kupperman scores, traditional Chinese medicine(TCM) syndrome scores, levels of sex hormones, including follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2),indexes of ovarian activity,including ovarian volume (OV),antral follicle counting (AFC) and anti- mullerian hormone (AMH), and incidence of adverse reactions were compared between the three groups. Results: After treatment, the total clinical effective rate was 92.50% in the observation group, higher than that of 70.00% in the control group A and 75.00% in the control group B (P<0.05). The Kupperman scores and TCM syndrome scores in the three groups were decreased when compared with those before treatment (P<0.05), and the above two scores in the observation group were lower than those in the control group A and the control group B respectively (P<0.05). The levels of FSH and LH in the three groups were decreased when compared with those before treatment (P<0.05),the E2 levels were increased when compared with those before treatment (P<0.05);the FSH and LH levels in the observation group were lower than those in the control group A and control group B (P<0.05), and the E2 level was higher than that in the control group A and the control group B (P<0.05). The OV in the three groups were increased when respectively compared with those before treatment (P<0.05), the AFC were increased when respectively compared with those before treatment (P<0.05), and the AMH level were increased when respectively compared with those before treatment (P<0.05);the OV in the observation group was larger than that in the control group A and the control group B (P<0.05),the AFC was larger than that in the control group A and the control group B (P<0.05),and the AMH level was higher than that in the control group A and the control group B (P<0.05). The incidence of gastrointestinal discomfort,distension of the breasts,body mass gain and headache in the observation group and the control group B were lower than those in the control group A (P<0.05). Conclusion:The therapy of modified Tiaojing Kangshuai Decoction combined with western medicine can mitigate the clinical symptoms of patients with hypovarianism of kidney deficiency and blood stasis type, adjust the levels of sex hormones and promote the recovery of ovarian activity,whose curative effect is better than that of single modified Tiaojing Kangshuai Decoction or western medicine,with good safety.