调经抗衰汤加减联合西药治疗卵巢功能减退临床研究
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R711.75

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Clinical Study on Modified Tiaojing Kangshuai Decoction Combined with Western Medicine for Hypovarianism
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    摘要:

    目的:观察调经抗衰汤加减联合西药治疗肾虚血瘀型卵巢功能减退的临床疗效。方法:选取 120 例肾虚血瘀型卵巢功能减退患者,根据随机数字表法分为对照A 组、对照B 组和观察组各40 例。对照A 组给予西药(戊酸雌二醇片、黄体酮胶囊) 治疗,对照B 组给予调经抗衰汤加减治疗,观察组同时给予调经 抗衰汤加减联合西药治疗,3 组均治疗3 个月经周期。比较3 组临床疗效、Kupperman 评分、中医证候积分、 性激素[卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)] 水平、卵巢功能指标[卵巢体积(OV)、窦 卵泡计数(AFC)、抗苗勒管激素(AMH)] 及不良反应发生率。结果:治疗后,观察组临床疗效总有效率 92.50%,高于对照A 组70.00%及对照B 组75.00%(P<0.05)。3 组Kupperman 评分、中医证候积分均较治疗 前降低(P<0.05),观察组Kupperman 评分、中医证候积分均低于对照A 组及对照B 组(P<0.05)。3 组 FSH、LH 水平均较治疗前降低(P<0.05),E2 水平均较治疗前升高(P<0.05);观察组FSH、LH 水平均低于 对照A 组及对照B 组(P<0.05),E2 水平高于对照A 组及对照B 组(P<0.05)。3 组OV 均较治疗前增 大(P<0.05),AFC 均较治疗前增多(P<0.05),AMH 水平均较治疗前升高(P<0.05);观察组OV 大于对照 A 组及对照B 组(P<0.05),AFC 多于对照A 组及对照B 组(P<0.05),AMH 高于对照A 组及对照B 组(P<0.05)。观察组与对照B 组胃肠不适、乳胀、体质量增加及头痛发生率均低于对照A 组(P<0.05)。结 论:调经抗衰汤加减联合西药治疗肾虚血瘀型卵巢功能减退,可缓解患者的临床症状,调节性激素水平,促进 卵巢功能恢复,其治疗效果优于仅使用调经抗衰汤加减或西药治疗,且安全性高。

    Abstract:

    Abstract:Objective:To observe the clinical effect of therapy of modified Tiaojing Kangshuai Decoction combined with western medicine on hypovarianism of kidney deficiency and blood stasis type. Methods:A total of 120 patients with hypovarianism of kidney deficiency and blood stasis type were selected and divided into the control group A,the control group B and the observation group according to the random number table method, with 40 cases in each group. The control group A was given western medicine, including Estradiol Valerate Tablets and Progesterone Capsules; the control group B was given modified Tiaojing Kangshuai Decoction,and the observation group was treated with the therapy of modified Tiaojing Kangshuai Decoction combined with western medicine. The three groups were treated for 3 menstrual cycles. The clinical effects, Kupperman scores, traditional Chinese medicine(TCM) syndrome scores, levels of sex hormones, including follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E2),indexes of ovarian activity,including ovarian volume (OV),antral follicle counting (AFC) and anti- mullerian hormone (AMH), and incidence of adverse reactions were compared between the three groups. Results: After treatment, the total clinical effective rate was 92.50% in the observation group, higher than that of 70.00% in the control group A and 75.00% in the control group B (P<0.05). The Kupperman scores and TCM syndrome scores in the three groups were decreased when compared with those before treatment (P<0.05), and the above two scores in the observation group were lower than those in the control group A and the control group B respectively (P<0.05). The levels of FSH and LH in the three groups were decreased when compared with those before treatment (P<0.05),the E2 levels were increased when compared with those before treatment (P<0.05);the FSH and LH levels in the observation group were lower than those in the control group A and control group B (P<0.05), and the E2 level was higher than that in the control group A and the control group B (P<0.05). The OV in the three groups were increased when respectively compared with those before treatment (P<0.05), the AFC were increased when respectively compared with those before treatment (P<0.05), and the AMH level were increased when respectively compared with those before treatment (P<0.05);the OV in the observation group was larger than that in the control group A and the control group B (P<0.05),the AFC was larger than that in the control group A and the control group B (P<0.05),and the AMH level was higher than that in the control group A and the control group B (P<0.05). The incidence of gastrointestinal discomfort,distension of the breasts,body mass gain and headache in the observation group and the control group B were lower than those in the control group A (P<0.05). Conclusion:The therapy of modified Tiaojing Kangshuai Decoction combined with western medicine can mitigate the clinical symptoms of patients with hypovarianism of kidney deficiency and blood stasis type, adjust the levels of sex hormones and promote the recovery of ovarian activity,whose curative effect is better than that of single modified Tiaojing Kangshuai Decoction or western medicine,with good safety.

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徐方丽,姜帅,喻向春.调经抗衰汤加减联合西药治疗卵巢功能减退临床研究[J].新中医,2023,55(18):87-92

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  • 在线发布日期: 2023-09-22
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