Abstract：Objective：To observe the clinical effect of Buqi Huoxue Prescription combined with Huolong Cupping for lumbar disc herniation (LDH) with cold-damp obstruction syndrome. Methods ： A total of 90 cases of LDH patients were selected and divided into the control group and the observation group according to the random number table method，with 45 cases in each group. During the research，2 cases lost follow- up in the control group， and finally， 43 cases completed the process； in the observation group， 2 cases did not take medicine as required and 1 case lost follow- up， and finally， 42 cases completed the research. The control group was treated with the oral administration of Celecoxib Capsules， and the observation group was treated with Buqi Huoxue Prescription combined with Huolong Cupping. Both groups were continuously treated for four weeks. Clinical effects and the incidence of adverse reactions were compared between the two groups. The scores of Visual Analogue Scale (VAS) for pain， Japanese Orthopaedic Association (JOA)，Oswestry Disability Index (ODI)，Pittsburgh Sleep Quality Index (PSQI)， and 36- Item Short Form Survey (SF- 36)， as well as the levels of β- endorphin (β- EP) and prostaglandin E2 (PGE2) were compared before and after treatment between the two groups. Results：The total effective rate was 95.24% in the observation group and 79.07% in the control group，the difference being significant (P＜0.05). After treatment，the scores of VAS and ODI in the two groups were decreased when compared with those before treatment (P＜0.05)，and JOA scores were increased when compared with those before treatment (P＜0.05)； the scores of VAS and ODI in the observation group were lower than those in the control group (P＜0.05)，and JOA score in the observation group was higher than that in the control group (P＜0.05). After treatment， the PSQI scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and SF-36 scores were increased when compared with those before treatment (P＜0.05)； the PSQI score in the observation group was lower than that in the control group (P＜0.05)，and SF-36 score in the observation group was higher than that in the control group (P＜0.05). After treatment，the levels of β-EP in serum in the two groups were increased when compared with those before treatment (P＜0.05)，and the levels of PGE2 were decreased when compared with those before treatment (P＜0.05)； the β- EP level in the observation group was higher than that in the control group (P＜0.05)，and PGE2 level in the observation group was lower than that in the control group (P＜0.05). The incidence of adverse reactions was 4.76% in the control group and 27.91% in the control group，the difference being significant (P＜0.05). Conclusion： Buqi Huoxue Prescription combined with Huolong Cupping for LDH with cold- damp obstruction syndrome can significantly relieve the pain symptom of patients and improve their lumbar vertebral function，sleep quality，and life quality，with good safety.