Abstract： Objective： To observe the clinical effect of Lianhua Qingwen Capsules combined with western medicine for mycoplasma pneumonia with heat toxin attacking the lung syndrome. Methods： A total of 104 cases of patients with mycoplasma pneumonia with heat toxin attacking the lung syndrome were selected and divided into the study group and the control group according to the random number table method， with 52 cases in each group. The control group was treated with western medicine， and the study group was additionally treated with Lianhua Qingwen Capsules based on the treatment of the control group. Both groups were treated for 7 days. The levels of immunoglobulin (Ig) and inflammatory indexes before and after treatment，as well as the clinical effects and symptom relief time were compared between the two groups. Results：After treatment，the total effective rate was 100% in the study group，higher than that of 90.38% in the control group (P＜0.05). The time of body temperature returning to normal， cough relief time，and disappearance time of wet rales in the study group were shorter than those in the control group (P＜0.05). After treatment，the levels of IgA，IgG，and IgM in serum in the two groups were increased when compared with those before treatment (P＜0.05)，and the levels of IgA，IgG，and IgM in serum in the study group were higher than those in the control group (P＜0.05). The levels of interleukin-6 (IL-6)，tumor necrosis factor-α (TNF-α)，C-reactive protein (CRP)，and neutrophil count (NE) in serum in the two groups were decreased when compared with those before treatment (P＜0.05)，and the levels of IL-6，TNF-α，CRP，and NE in serum in the study group were lower than those in the control group (P＜ 0.05). Conclusion： Compared with western medicine， the additional treatment of Lianhua Qingwen Capsules for mycoplasma pneumonia with heat toxin attacking the lung syndrome can improve the clinical effect，promote the relief of clinical symptoms，improve the immune function of patients，and reduce the inflammatory responses of the body.