Abstract： Objective： To observe the clinical effect of kneecaps with Chinese medicine on knee osteoarthritis (KOA). Methods： A total of 120 KOA patients were given retrospective analysis and divided into the control group， the trial group A and the trial group B according to different treatment methods， with 40 cases in each group. The three groups were given oral administration of Celecoxib Capsules for relieving inflammation and pain，the trial group A was treated with hot compress of kneecaps with Chinese medicine and the trial group B was given hot compress of common moxa salt package. Both three groups were treated for 3 weeks. The scores of Visual Analogue Scale (VAS) for pain， Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Lysholm before treatment， and at the seventh and fourteenth days of treatment were compared between the three groups；the clinical effects and incidence of adverse reactions were compared between the three groups. Results：Before treatment，there was no significant difference being found in the comparison of VAS score between the three groups (P＞0.05)；at the seventh and fourteenth days of treatment， the VAS scores in the three groups were gradually decreased (P＜0.05)，the VAS score in the trial group A was lower than that in the trial group B (P＜0.05) and the VAS score in the trial group B was lower than that in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of WOMAC score between the three groups (P＞0.05)； at the seventh and fourteenth days of treatment， the WOMAC scores in the three groups were gradually decreased (P＜0.05)，the WOMAC score in the trial group A was lower than that in the trial group B (P＜0.05) and the WOMAC score in the trial group B was lower than that in the control group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of Lysholm score between the three groups (P＞0.05)；at the seventh and fourteenth days of treatment，the Lysholm scores in the three groups were gradually increased (P＜0.05)，the Lysholm score in the trial group A was higher than that in the experiment group B (P＜0.05) and the Lysholm score in the trial group B was higher than that in the control group (P＜0.05). The total effective rate was 97.50% in the trial group A， higher than that of 80.00% in the trial group B (χ 2=6.134，P=0.013)；the total effective rate in the trial group B was higher than that of 77.50% in the control group (χ 2=0.075，P=0.785). There was no obvious adverse reaction in the three groups. Conclusion： The kneecaps with Chinese medicine for KOA can effectively mitigate the knee pain and improve the function of knees with good safety.