Abstract：Objective：To observe the clinical effect of Weisu Granules in adjuvant treatment of patients with advanced gastric cancer undergoing chemotherapy. Methods： A total of 80 cases of patients with advanced gastric cancer were selected as the study objects，and were divided into the observation group and the control group according to different treatment methods，with 40 cases in each group. The control group was treated with routine chemotherapy， and the observation group was additionally treated with Weisu Granules based on the treatment of the control group. Both groups were treated for 12 weeks. The clinical effects and adverse reactions were compared between the two groups. Before and after treatment， the lymphocyte ratio of CD4 + and CD8 + ， CD4 +/CD8 + ， and Quality of Life Questionnaire of European Organization for Research and Treatment (EORTC QLQ- C30) scores were compared between the two groups. The mortality and recurrence rates in the two groups were recorded during 1- year follow- up. Results：The total effective rate was 77.50% in the observation group，lower than that of 47.50% in the control group (P＜0.05). After treatment， CD4 + and CD4 +/CD8 + in the two groups were increased (P＜ 0.05)，and CD8+ was decreased (P＜0.05)；CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group (P＜0.05)， and CD8 + was lower than that in the control group (P＜0.05). The adverse reactions including gastrointestinal reactions，neurotoxicity，myelosuppression，and liver function damage in the two groups were mostly gradeⅠorⅡ，and there was no significant difference between the two groups (P＞0.05). After treatment， EORTC QLQ- C30 scores in the two groups were increased (P＜ 0.05)，and the above score in the observation group was higher than that in the control group (P＜0.05). The recurrence rate in the observation group was lower than that in the control group (P＜0.05). There was no significant difference being found in the comparison of mortality between the two groups (P＞0.05). Conclusion： Weisu Granules in adjuvant treatment of patients with advanced gastric cancer undergoing chemotherapy can enhance the total clinical effective rate and quality of life，improve the immune function of patients，and reduce the recurrence rate，with good safety.