Abstract： Objective： To observe the curative effect of the therapy of Hewei Huashi Decoction combined with Houpu Sanwu Decoction on chronic atrophic gastritis (CAG) and its effect on nuclear transcription factor- κB (NF- κB) and B- cell lymphoma 2 (Bcl- 2) pathway. Methods： A total of 120 CGA patients were selected and divided into the control group and the observation group according to the random number table method， with 60 cases in each group. The control group was given routine symptomatic treatment， and the observation group was additionally treated with oral administration of Hewei Huashi Decoction combined with Houpu Sanwu Decoction based on the treatment of the control group. Both groups were treated for 1 month. The clinical effects in the two groups were evaluated； the traditional Chinese medicine syndrome scores，levels of serum pepsinogenⅠ(PGⅠ) and pepsinogenⅡ(PGⅡ)，and changes of PG Ⅰ/PG Ⅱ， NF- κB in gastric mucosa and Bcl- 2 protein were compared before and after treatment between the two groups；the incidence of adverse reactions was observed. Results：The total effective rate was 93.33% in the observation group，higher than that of 78.33% in the control group (P＜ 0.05). After treatment， the scores of stuffiness and distension of gastric cavity， nausea and vomiting， bitter taste and fetid breath，sloppy stool and scorching heat in the gastric cavity in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above five scores in the observation group were lower than those in the control group (P＜0.05). After treatment，the serum PGⅠ levels and PGⅠ/PGⅡ in both groups were increased when compared with those before treatment，and the serum PG II levels were decreased when compared with those before treatment (P＜0.05)；the serum PG Ⅰ level and PG Ⅰ/PG Ⅱ in the observation group were higher than those in the control group， and the serum PG II level was lower than that in the control group (P＜0.05). After treatment， the positive expression rates of NF-κB and Bcl-2 protein in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above two rates in the observation group were lower than those in the control group (P＜0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups (P＞0.05). Conclusion：The therapy of Hewei Huashi Decoction combined with Houpu Sanwu Decoction has a definite curative effect on CAG with good safety，which can help decrease the atrophic degree of gastric mucosa and recover the gastric mucosa，whose mechanism may be related to the inhibition of activation of NF-κB/Bcl-2 signal pathway.