Abstract： Objective： To observe the clinical effect of Anshen Tongqiao Decoction combined with lithium carbonate for manic episode in patients with bipolar disorder. Methods： A total of 100 cases of patients with phlegm stasis block type manic episode in bipolar disorder were selected as the study objects and divided into the routine treatment group and the Anshen Tongqiao group according to the random number table method，with 50 cases in each group. The routine treatment group was simply treated with lithium carbonate， and the Anshen Tongqiao group was additionally treated with Anshen Tongqiao Decoction based on the treatment of the routine treatment group. Both two groups were treated for 8 weeks. Clinical effects and adverse reactions were compared between the two groups. Changes in levels of inflammatory factors in serum， quality of life， and mania degrees before and after treatment were compared between the two groups. Results：The total effective rate was 96.00% in the Anshen Tongqiao group，higher than that of 84.00% in the routine treatment group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of brain- derived neurotrophic factor (BDNF)，interleukin-1β (IL-1β)，and tumor necrosis factor-α (TNF-α) in serum between the two groups (P＞0.05). After treatment，the levels of BDNF in serum in the two groups were increased (P＜0.05)，and the levels of IL- 1β and TNF- α were decreased (P＜0.05)； the level of BDNF in serum in the Anshen Tongqiao group was higher than that in the routine treatment group (P＜0.05)，and the levels of IL-1β and TNF- α in the Anshen Tongqiao group were lower than those in the routine treatment group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of the scores of Hopkins Verbal Learning Test-Revised (HVLT-R) and Continuous Performance Test (CPT) between the two groups (P＞0.05). After treatment，the scores of HVLT-R and CPT in the two groups were increased (P＜ 0.05)，and the scores in the Anshen Tongqiao group were higher than those in the routine treatment group (P＜0.05). Before treatment， there was no significant difference being found in the comparison of the scores of 36- Item Short Form Health Survey (SF- 36) and Bech- Rafaelsen Mania Rating Scale (BRMS) between the two groups (P＞0.05). After treatment，the scores of SF-36 in the two groups were increased (P＜0.05)，and BRMS scores were decreased (P＜0.05)；SF-36 score in the Anshen Tongqiao group was higher than that in the routine treatment group (P＜0.05)，and BRMS score in the Anshen Tongqiao group was lower than that in the routine treatment group (P＜0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups (P＞0.05). Conclusion： Anshen Tongqiao Decoction combined with lithium carbonate for manic episode in patients with bipolar disorder can improve clinical effects，quality of life，attention，and learning ability of patients and reduce the degree of mania， whose mechanism may be related to its adjustments of serum neurotrophin levels and inflammatory reactions.