健脾化痰方联合认知训练治疗帕金森病轻度认知障碍临床研究
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R742.5

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Clinical Study on Jianpi Huatan Prescription Combined with Cognitive Training for Mild Cognitive Impairment in Parkinson's Disease
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    摘要:

    目的:观察健脾化痰方联合认知训练治疗帕金森病轻度认知障碍的临床疗效及对日常生活活动能 力的影响。方法:选取74 例帕金森病轻度认知障碍患者,按随机数字表法分为对照组和观察组各37 例。对照 组采取常规康复治疗与认知训练,观察组在对照组基础上联合健脾化痰方治疗。2 组均治疗4 周。比较2 组治 疗前后中医证候积分、帕金森病评定量表(UPDRS)、简易智力状态检查量表(MMSE)、蒙特利尔认知评估量 表(MoCA) 和日常生活活动能力Barthel 指数评分,评价2 组临床疗效,比较2 组不良反应发生情况。结果: 观察组总有效率为94.59%,高于对照组75.68%(P<0.05)。治疗后,2 组痰多吐涎、纳呆腹胀、肢体困重、 头晕耳鸣等评分较治疗前降低(P<0.05),且观察组各项评分低于对照组(P<0.05)。治疗后,2 组UPDRS-Ⅰ、 UPDRS-Ⅱ、UPDRS-Ⅲ评分较治疗前降低(P<0.05),且观察组UPDRS-Ⅰ、UPDRS-Ⅱ、UPDRS-Ⅲ评分均 低于对照组(P<0.05)。治疗后,2 组MMSE、MoCA、Barthel 指数评分较治疗前升高(P<0.05),且观察组 MMSE、MoCA、Barthel 指数评分均高于对照组(P<0.05)。2 组不良反应发生率比较,差异无统计学意 义(P>0.05)。结论:健脾化痰方联合认知训练治疗帕金森病轻度认知障碍的疗效显著,能延缓帕金森疾病的 进展,改善其临床症状和智力,提高认知功能和日常生活活动能力,安全性高。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Jianpi Huatan Prescription combined with cognitive training for mild cognitive impairment in Parkinson's disease and its effects on activities of daily life. Methods: A total of 74 cases of patients with mild cognitive impairment in Parkinson's disease were selected and divided into the control group and the observation group according to the random number table method,with 37 cases in each group. The control group was treated with routine rehabilitation training and cognitive training,and the observation group was additionally treated with Jianpi Huatan Prescription based on the treatment of the control group. Both groups were treated for 4 weeks. Traditional Chinese medicine syndrome scores and the scores of Unified Parkinson's Disease Rating Scale (UPDRS),Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Barthel Index for Activities of Daily Living were compared before and after treatment between the two groups. Clinical effects were evaluated in the two groups, and the incidence of adverse reactions was compared between the two groups. Results:The total effective rate was 94.59% in the observation group,higher than that of 75.68% in the control group (P<0.05). After treatment,the scores of excessive phlegm and drooling,torpid intake and abdominal distension, heaviness and weakness of limbs, dizziness and tinnitus in the two groups were decreased when compared with those before treatment (P<0.05),and the above scores in the observation group were lower than those in the control group (P<0.05). After treatment, the scores of UPDRS- Ⅰ, UPDRS- Ⅱ , and UPDRS- Ⅲ in the two groups were decreased when compared with those before treatment (P<0.05),and the above scores in the observation group were lower than those in the control group (P<0.05). After treatment,the scores of MMSE,MoCA,and Barthel Index in the two groups were increased when compared with those before treatment (P<0.05),and the above scores in the observation group were higher than those in the control group (P<0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Jianpi Huatan Prescription combined with cognitive training has a significant curative effect in the treatment of mild cognitive impairment in Parkinson's disease, which can delay the progression of Parkinson's disease, improve the clinical symptoms and intelligence of patients, enhance cognitive function and activities of daily living,and has high safety.

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徐青青,朱斌,计静,林初勇,陈世宣.健脾化痰方联合认知训练治疗帕金森病轻度认知障碍临床研究[J].新中医,2023,55(17):91-95

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  • 在线发布日期: 2023-09-07
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