Abstract： Objective： To observe the clinical effect of Ginkgolides Injection combined with routine western medicine for ischemic stroke. Methods：A total of 79 cases of patients with ischemic stroke were selected and divided into the control group and the observation group according to the random number table method， with 39 and 40 cases in each group respectively. The control group was treated with routine western medicine，and the observation group was additionally treated with Ginkgolides Injection based on the treatment of the control group. Both groups were treated for 14 days. The clinical effects in the two groups were evaluated. Before and after treatment， blood brain barrier function， brain injury markers， neurological impairment， cognitive function， and platelet function were compared between the two groups. Results：The total effective rate was 95.00% in the observation group，higher than that of 76.92% in the control group (P＜0.05). After treatment， the indexes of cerebrospinal fluid albumin， serum albumin， and blood- brain barrier in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above indexes in the observation group were lower than those in the control group (P＜0.05). After treatment，the levels of neuron- specific enolase (NSE) and S100 calcium- binding protein B (S100B) in the two groups were decreased when compared with those before treatment (P＜ 0.05)，and the levels of NSE and S100B in the observation group were lower than those in the control group (P＜0.05). After treatment，the scores of National Institute of Health Stroke Scale (NIHSS) in the two groups were decreased when compared with those before treatment， and the scores of Mini- Mental State Examination (MMSE) were increased when compared with those before treatment (P＜0.05)；NIHSS score in the observation group was lower than that in the control group，and MMSE score was higher than that in the control group (P＜0.05). After treatment， platelet adhesion rates and platelet aggregation rates in the two groups were decreased when compared with those before treatment (P＜0.05)， and the platelet adhesion rate and platelet aggregation rate in the observation group were lower than those in the control group (P＜0.05). There was no significant difference being found in the comparison of the incidence of adverse reactions between the two groups (P＞0.05). Conclusion： Ginkgolides Injection combined with routine western medicine for ischemic stroke can improve the blood- brain barrier function， reduce brain injury，and improve the cognitive function of patients with good safety.