Abstract：Objective：To observe the clinical effect of the therapy of Shaofu Zhuyu Decoction combined with small-dose Tadalafil on erectile dysfunction (ED) in peritoneal dialysis patients. Methods： A total of 68 male peritoneal dialysis patients with ED were selected and divided into the observation group and the control group according to random number table method，with 34 cases in each group. The control group was given small- dose of Tadalafil， and the observation group was additionally given Shaofu Zhuyu Decoction based on the treatment of the control group. Both groups were treated for 30 days. The clinical effects in the two groups were evaluated. The scores of International Index of Erectile Function-5 (IIEF-5)， the scores of Erection Hardness Grading Scale (EHS)， traditional Chinese medicine (TCM) syndrome scores， penile hemodynamic parameters， including peak systolic velocity (PSV)， end- diastolic velocity (EDV)， resistance index (RI) and deep dorsal vein velocity (VV)， and oxidative stress indexes， including malonaldehyde (MDA)， superoxide dismutase (SOD) and nitric oxide (NO)， were compared between the two groups before and after treatment. The adverse reactions were also recorded. Results： The total effective rate was 88.24% in the observation group，higher than that of 73.53% in the control group (P＜ 0.05). After treatment，the IIEF-5 and EHS scores in the two groups were increased when compared with those before treatment，and those in the observation group were higher than those in the control group (P＜ 0.05)； the TCM syndrome scores in the two groups were decreased when compared with those before treatment，and the scores in the observation group were lower than those in the control group (P＜0.05). After treatment，the PSV and RI levels in the two groups were increased when compared with those before treatment，and the above levels in the observation group were higher than those in the control group (P＜ 0.05)； the EDV and VV levels in the two groups were decreased when compared with those before treatment，and the above levels in the observation group were lower than those in the control group (P＜ 0.05). After treatment， the SOD and NO levels in the two groups were increased when compared with those before treatment，and the above two levels in the observation group were higher than those in the control group (P＜0.05)； the MDA levels in the two groups were decreased when compared with those before treatment，and the level in the observation group was lower than that in the control group (P＜0.05). The incidence of adverse reactions in the observation group was 5.88%，lower than that of 14.71% in the control group (P＜0.05). Conclusion： The therapy of Shaofu Zhuyu Decoction combined with small- dose Tadalafil has a definite therapeutic effect on the treatment of peritoneal dialysis complicated with ED，which can effectively improve penile hemodynamics and oxidative stress state.