Abstract： This paper introduces the clinical experience of Professor MAO Dexi in treating obesity complicated with non- alcoholic fatty liver disease (NAFLD) based on syndrome differentiation. Professor MAO Dexi believes that the pathological characteristics of obesity complicared with NAFLD lie in that deficiency is the root，dampness and depression are the symptom，and dampness often runs through the whole pathological process. Therefore，it is often treated from deficiency，dampness，and stagnation. And Professor MAO created five methods， namely soothing the liver， regulating qi and resolving dampness method，clearing heat and draining dampness method，dissipating cold and dispelling dampness method， warming yang and draining dampness method， and dissipating blood stasis and draining dampness method. In clinical practice， multiple methods are combined to treat based on syndrome differentiation， with dispelling dampness throughout，and a good clinical effect can be obtained.