Abstract： From the perspective of "three factors" medical model， based on Shi Re Lun (Treatise on Damp- Heat Diseases) and combined with the climate， geographical and cultural environment in Lingnan Area， the etiology and pathogenesis of stroke in Lingnan area were analyzed in this paper. In terms of "heaven environment"， the high temperature in Lingnan area is the source of multiple incidence of heat syndrome； in terms of "earth environment"， dampness in Lingnan area is the root cause of multiple incidence of pathogenic dampness； in terms of "human environment"， the weakness of the spleen and stomach in Lingnan area is the root cause of multiple incidence of damp- heat. "Heaven environment" and "earth environment" are important causes of the occurrence and development of stroke in Lingnan area， and "human environment" is the fundamental cause. The deficiency of healthy qi and the division and combination of damp-heat are the key pathogenesis affecting the transformation of stroke in Lingnan area.