Abstract： Objective： To observe the clinical effect of retention enema with Qingchang Yuyang Decoction combined with point application with Changyu Fang for ulcerative colitis (UC) with large intestinal dampness- heat syndrome and its effect on serum inflammatory factors. Methods：A total of 80 cases of UC patients with large intestinal dampness-heat syndrome were selected and divided into the observation group and the control group according to the random number table method，with 40 cases in each group. The control group was given the oral administration of Mesalazine，and the observation group was treated with retention enema with Qingchang Yuyang Decoction combined with point application with with Changyu Fang. Both groups were treated for three months. The changes in the levels of serum inflammatory factors [tumor necrosis factor-α (TNF-α)，interleukin-1 (IL-1)，interleukin-6 (IL-6)]，and T lymphocyte subsets in peripheral blood (CD4+，CD8+，CD4+/CD8+) before and after treatment，as well as the clinical effects and recurrence in the two groups were compared. Results： The total effective rate was 95.00% in the observation group and 80.00% in the control group， the difference being significant (P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of CRP，TNF-α， IL-1，and IL-6 in serum between the two groups (P＞0.05)；after treatment，all the above indexes in the two groups were decreased when compared with those before treatment (P＜0.05)，and the four indexes in the observation group were lower than those in the control group (P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of CD4 + ， CD8 + ， and CD4 +/CD8 + between the two groups (P＞0.05)；after treatment，the above indexes in the two groups were increased when compared with those before treatment (P＜0.05)， and the indexes in the observation group were higher than those in the control group (P＜0.05). After six months of follow- up，the recurrence rate was 5.26% in the observation group and 28.13% in the control group，the difference being significant (P＜0.05). Conclusion：The retention enema with Qingchang Yuyang Decoction combined with point application with Changyu Fang for UC with large intestinal damp-heat syndrome can enhance the clinical effect，effectively reduce the levels of serum inflammatory factors，improve the immune function of patients，and reduce the recurrence rate.