Abstract：Objective：To observe the clinical effect of musculoskeletal ultrasound- guided acupotomy for tenosynovitis strictus flexor of fingers (TF) and its influence on hand function rehabilitation. Methods：A total of 80 TF patients were selected as study objects and divided into the observation group and the control group according to random number table method， with 40 cases in each group. The control group was given traditional acupotomy release treatment， and the observation group was given musculoskeletal ultrasound- guided acupotomy release treatment. The clinical effects， Quinnell grading score of finger function， recovery of blood flow and sensation， joint bounces and locking， pain， self- care ability and complications in the two groups were compared. Results： The total effective rate was 100% in the observation group and 90.00% in the control group，the difference being significant (P＜0.05). One month after surgery，the Quinnell grading score in the observation group was lower than that in the control group (P＜0.05)； the capillary filling recovery time and sensory recovery time in the observation group were shorter than those in control group (P＜0.05)； the incidence of joint bounces and joint locking in the observation group was respectively lower than that in the control group (P＜0.05)； the Visual Analogue Scale (VAS) score in the observation group was lower than that in the control group (P＜0.05)， and the Barther index was higher than that in the control group (P＜0.05). One month after surgery，there was no complication in the observation group， and the complication rate in the control group was 10.00% ， the difference being significant (P＜0.05). Conclusion： Musculoskeletal ultrasound- guided acupotomy can improve clinical effect on TF，effectively relieve the pain of the affected fingers and reduce joint bounces and locking， thereby improving patients self- care ability and advancing functional rehabilitation of the affected fingers，without complications.