Abstract： Objective： To observe the clinical effect of warming- needle moxibustion for knee osteoarthritis (KOA) of cold-damp obstruction type and its effect on the levels of serum inflammatory factors. Methods：A total of 132 cases of patients with KOA of cold- damp obstruction type were divided into the control group and the observation group according to the random number table method，with 66 cases in each group. The control group was treated with Ibuprofen Sustained- Release Capsules ， and the observation group was additionally treated with warming-needle moxibustion based on the treatment of the control group. Before and after treatment，the symptom scores，the Visual Analogue Scale (VAS) scores of pain，the levels of serum inflammatory indexes [hypersensitive C-reactive protein (hs-CRP)，interleukin-6 (IL- 6)，erythrocyte sedimentation rate (ESR)]，and the knee joint range of motion (ROM) were compared between the two groups. The clinical effects and the incidence of adverse reactions in the two groups were observed. Results：The total effective rate was 86.36% in the observation group and 71.21% in the control group，the difference being significant (P＜0.05). After treatment，the scores of joint swelling，joint pain， joint stiffness， inhibited flexion and extension in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above scores in the observation group were lower than those in the control group (P＜0.05). After treatment， VAS scores in the two groups were decreased when compared with those before treatment (P＜0.05)，and VAS score in the observation group was lower than that in the control group (P＜0.05). After treatment， the levels of hs- CRP， IL- 6， and ESR in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above levels in the observation group were lower than those in the control group (P＜0.05). After treatment，knee joint ROM values in the two groups were increased when compared with those before treatment，and the ROM value in the observation group was higher than that in the control group (P＜0.05). The incidence of adverse reactions was 1.52% in the observation group and 10.61% in the control group， the difference being significant (P＜0.05). Conclusion： Warming- needle moxibustion has a significant curative effect in the treatment of KOA of cold- damp obstruction type，which can effectively relieve clinical symptoms，pain， and inflammatory responses and improve joint ROM，with high safety.