Abstract：Objective：To observe the clinical effect of therapy of Yijinjing conduction exercise combined with Yiqi Jianpi Bushen Prescription on cancer- related fatigue (CRF) with lung- spleen qi deficiency syndrome after surgery of lung cancer. Methods：A total of 76 cases of CRF patients with lung- spleen qi deficiency syndrome after surgery of lung cancer were selected and randomly divided into the treatment group and the control group according to the sealed envelope method， with 38 cases in each group. During the study， 3 cases were removed，1 case dropped off and eventually 34 cases were included in the treatment group；5 cases were removed，1 case dropped off and eventually 32 cases were included in the control group. The treatment group was given the therapy of Yijinjing conduction exercise combined with Yiqi Jianpi Bushen Prescription， and the control group was only treated with Yiqi Jianpi Bushen Prescription. Both groups were treated for 2 months. Before and after treatment， the scores of Multidimensional Fatigue Symptoms Inventory- Short Form (MFSI- SF) and Functional Assessment of Cancer Therapy-Lung cancer (FACT-L) and the cellular immune function were compared between the two groups. Results：After treatment，the scores of general fatigue，emotional fatigue，physical fatigue and psychological fatigue and the total scores of fatigue in the two groups were decreased when compared with those before treatment， and the scores of vitality were increased when compared with those before treatment， differences being significant (P＜0.05)； the scores of general fatigue， physical fatigue and psychological fatigue and the total score of fatigue in the treatment group were lower than those in the control group (P＜0.05)，and the score of vitality was higher than that in the control group (P＜0.05)；there was no significant difference being found in the comparison of emotional fatigue scores between the two groups (P＞0.05). The scores of physiological well-being (PWB)，emotional well-being (EWB)，functional well-being (FWB) and lung cancer symptoms (LCS) and total scores in both groups，as well as the score of social well- being (SWB) in the treatment group were increased when compared with those before treatment， and the scores of PWB， EWB， FWB and LCS and total score in the treatment group were higher than those in the control group， differences being significant (P＜0.05)； there was no significant difference being found in the comparison of SWB score between the two groups (P＞0.05). The improvement of serum CD3 + level in the treatment group was better than that in the control group， the difference being significant (P＜0.05). There was no significant difference being found in the comparison of improvement of CD4+/CD8+ value and level of serum natural killer (NK) cell (P＞0.05). Conclusion：Yijinjing conduction exercise combined with Yiqi Jianpi Bushen Prescription can effectively improve the clinical symptoms of CRF patients with lung-spleen qi deficiency syndrome after surgery of lung cancer，enhance their quality of life and cellular immune function.