基于数据挖掘研究沈力治疗胃癌用药规律
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R735.2

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浙江省沈力名老中医工作室建设项目(GZS2012031);宁波市第二医院“华美中医研究基金”项目(2022HMZY104);浙江省中医药 科技计划项目(2023ZF044)


Study on Medication Rules of SHEN Li in Treating Gastric Cancer Based on Data Mining
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    摘要:

    目的:基于统计分析、数据挖掘与回顾性研究的方法,对沈力教授治疗胃癌的医案进行研究,探 索胃癌的病机与治则治法,总结沈力教授治疗胃癌的用药规律。方法:收集沈力教授2018 年9 月1 日—2021 年 8 月31 日在宁波市第二医院门诊诊治的全部胃癌患者的临床资料。将所得资料输入Microsoft Excel 中建立方药 数据库,录入所有符合标准的处方药物、功效等,应用SPSS19.0 统计学软件及用古今医案云平台对药物的药 味、药性、功效等进行频数分析,对高频药物进行聚类分析、复杂网络分析。结果:获得1 213 首处方共涉及 中药115 种,总用药频次18 793 次,用药频率>50%的中药有10 味,依次为枸杞子、南方红豆杉、炙甘草、 炒山楂、绞股蓝、炒稻芽、佛手、炒麦芽、徐长卿、猫人参。用药药性以平、温为主,药味以甘、苦、辛为 主,多归脾、胃、肝、肺经。药物功效以补虚、清热解毒、消食为主。经聚类分析,获得9 个聚类方。经复杂 网络分析获得核心方组成为南方红豆杉、炙甘草、枸杞子、炒山楂、绞股蓝、炒稻芽、炒麦芽、徐长卿、半枝 莲、白花蛇舌草、猫人参、佛手、藤梨根。结论:沈力教授治疗胃癌用药,以补虚、清热解毒、消食、缓解症 状为重要组成,四者相辅相成,标本兼治。

    Abstract:

    Abstract: Objective: Based on the methods of statistical analysis, data mining and retrospective study,the medical records of Prof. SHEN Li in treating gastric cancer were studied;the pathogenesis and treatment methods of gastric cancer were explored, and the medication rules of Prof. SHEN in treating gastric cancer were summarized. Methods:The clinical data of all gastric cancer patients treated by Prof. SHEN in the outpatient department of Ningbo No.2 Hospital from September 1,2018 to August 31,2021 were collected. The obtained data were input into the prescription database established in Microsoft Excel, and all the prescription drugs and effects conforming to the standards were input. The SPSS19.0 statistical software and the cloud platform of ancient and modern medical records were used to analyze the frequency of flavors, natures and effects, and cluster analysis and complex network analysis were conducted for high- frequency drugs. Results: A total of 1,213 prescriptions involving 115 kinds of Chinese medicinals were obtained. The total frequency of herbal use was 18,793 times,and the frequency of herbal use over 50% were 10 kinds of Chinese medicinals, which were Lycii Fructus, Taxus wallichiana var. Mairei, Glycyrrhizae Praeparata Radix et Rhizoma cum Melle, fried Crataegi Fructus, Rhizoma seu Herba Gynostemmatis Pentaphylli, fried Oryzae Fructus Germinatus, Citri Sarcodactylis Fructus, fried Hordei Fructus Germinatus,Cynanchi Paniculati Radix et Rhizoma and Actinidia valvata Dunn. The natures of the herbs were mainly mild and warm;the flavors were mainly sweet,bitter and acrid,and the main channel entries were into the spleen,stomach,liver and lung. The effects of the herbs were mainly to supplement deficiency , clear heat and resolve toxin , and promote digestion. After cluster analysis , 9 clustering prescriptions were obtained. Through complex network analysis, the core prescription was composed of Taxus wallichiana var. Mairei, Glycyrrhizae Praeparata Radix et Rhizoma cum Melle, Lycii Fructus, fried Crataegi Fructus,Rhizoma seu Herba Gynostemmatis Pentaphylli,fried Oryzae Fructus Germinatus,fried Herba Ephedrae, Cynanchi Paniculati Radix et Rhizoma, Scutellariae Barbatae Herba, Hedyotis Diffusae Herba, Actinidia valvata Dunn, Fructus Citri Sarcodactylis and Actinidia arguta (Sieb. & Zucc) Planch. ex Miq. Conclusion: When Prof. SHEN treats gastric cancer, he mainly focuses on supplementing deficiency, clearing heat and resolving toxin, and promoting digestion as well as relieving symptoms, which complement each other and treat the root and branch simultaneously.

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王帅,厉欢松,屠晶晶,张晋.基于数据挖掘研究沈力治疗胃癌用药规律[J].新中医,2023,55(16):105-110

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  • 在线发布日期: 2023-08-31
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