Abstract： Objective： To observe the clinical effect of Guishao Shoutai Prescription combined with progesterone and low molecular weight heparin calcium injection for recurrent spontaneous abortion and its effect on pregnancy outcome. Methods：A total of 80 cases of patients with recurrent spontaneous abortion were selected as the study subjects and randomly divided into the control group and the trial group according to the random number table method，with 40 cases in each group. The control group was treated with progesterone and low molecular weight heparin calcium injection，and the trial group was additionally treated with Guishao Shoutai Prescription based on the treatment of the control group. The traditional Chinese medicine (TCM) syndrome scores，coagulation function [fibrinogen (Fib) and D-dimer (D-D)]，and sex hormones levels [estrogen (E2)，progesterone (P) and β-human chorionic gonadotropin (β-hCG)] before and after treatment， as well as clinical effects and pregnancy outcome were observed between the two groups. Results：The total effective rate was 95.00% in the trial group and 80.00% in the control group， the difference being significant (P＜0.05). After treatment， the scores of main and secondary symptoms and the total scores in TCM syndromes in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above scores in the trial group were lower than those in the control group (P＜0.05). After treatment，the levels of Fib and D- D in plasma in the two groups were decreased when compared with those before treatment (P＜0.05)， and the levels of Fib and D- D in the trial group were lower than those in the control group (P＜0.05). After treatment，the levels of E2，P and β- HCG in serum in the two groups were increased when compared with those before treatment (P＜0.05)，and the levels of E2，P and β-HCG in the trial group were higher than those in the control group (P＜0.05). Following up until the end of pregnancy，the full-term productivity was 82.50% in the trial group，and 50.00% in the control group，the difference being significant (P＜0.05). The abortion rate and premature delivery rate were 5.00% and 10.00% respectively in the trial group， and 20.00% and 30.00% respectively in the control group， differences being significant (P＜0.05). Conclusion： Guishao Shoutai Prescription combined with progesterone and low molecular weight heparin calcium injection has a definite curative effect in treating recurrent spontaneous abortion，which can effectively improve TCM syndromes，coagulation function and sex hormones levels with better pregnancy outcome.