Abstract： Objective： To observe the clinical effect of Shugan Hewei Decoction combined with Teprenone Capsules on chronic atrophic gastritis (CAG) with syndrome of liver- stomach disharmony. Methods：A total of 110 CAG patients with syndrome of liver- stomach disharmony were divided into the treatment group and the control group according to the random number table method， with 55 cases in each group. The patients infected with helicobacter pylori (Hp) were treated with quadruple chemotherapy， the control group was additionally given Teprenone Capsules for treatment，and the treatment group was additionally given Shugan Hewei Decoction based on the treatment of the control group. Both groups were treated for 1 month. The clinical effects， traditional Chinese medicine (TCM) syndrome scores， levels of gastrin (GAS) and pepsinogen (PG)I and PGII， values of PGI/PGII， and levels of inflammatory indexes including interleukin-6 (IL-6) and hypersensitive-C reactive protein (hs-CRP) were compared between the two groups. Results：After treatment，the total clinical effective rate was 90.91% in the treatment group， higher than that of 76.36% in the control group (P＜0.05). The scores of epigastric pain or distension， distension and fullness in both rib- sides， frequent eructation， emotional disorders， vexation， and frequent sighing in both groups were decreased when compared with those before treatment (P＜0.05)， the above six TCM syndrome scores in the treatment group were lower than those in the control group (P＜ 0.05). The levels of plasma GAS and serum PGⅠ，and PGⅠ/PGⅡ values in the two groups were increased when compared with those before treatment (P＜0.05)，and the serum PG II levels were decreased when compared with those before treatment (P＜0.05)；the levels of plasma GAS and serum PGⅠ，and PGⅠ/ PGⅡ values in the treatment group were higher than those in the control group (P＜0.05)，and the serum PGⅡ level was lower than that in the control group (P＜0.05). The levels of serum IL-6 and hs-CRP in both groups were decreased when compared with those before treatment (P＜0.05)，and the above 2 levels in the treatment group were lower than those in the control group (P＜0.05). Conclusion： Based on Teprenone Capsules， Shugan Hewei Decoction is additionally used to treat CAG with syndrome of liverstomach disharmony， which can enhance the clinical effect， effectively mitigate the symptoms of patients，regulate the levels of GAS and PG of the body and reduce the inflammatory responses.