Abstract:Objective:To observe the clinical effect of Yiqi Jiedu Agent combined with point application for qi deficiency constitution complicated with repeated colds. Methods: A total of 130 cases of patients with qi deficiency constitution complicated with repeated colds were selected and divided into two groups according to the random number table method,with 65 cases in each group. The control group was given oral administration of Yiqi Jiedu Agent,and the treatment group was treated with oral administration of Yiqi Jiedu Agent combined with point application. Both groups were treated for 50 days. Before treatment,at the end of treatment, and at the twelfth month of follow- up after treatment, the clinical effect of qi deficiency constitution,scores of clinical manifestation of qi deficiency constitution,T lymphocyte subsets of peripheral blood (CD3+,CD4+ and CD4+/CD8+),annual frequency and incidence of colds were compared between the two groups. Results: At the end of treatment and at the twelfth month of follow- up after treatment, there were significant differences being found in the comparison of the clinical effect in the treatment group and the control group (P<0.05). At the end of treatment and at the twelfth month of follow- up after treatment,the scores of clinical manifestation of qi deficiency constitution in the two groups were decreased when compared with those before treatment, CD3 + , CD4 + and CD4 +/CD8 + were increased when compared with those before treatment, and CD3 + , CD4 + and CD4 +/CD8 + in the treatment group were higher than those in the control group,differences being significant (P<0.05). At the twelfth month of follow-up after treatment,the annual frequency and incidence of colds in the two groups were decreased when compared with those before treatment, and the annual frequency and incidence of colds in the treatment group were lower than those in the control group, differences being significant (P<0.05). Conclusion: Yiqi Jiedu Agent combined with point application can improve qi deficiency constitution and immune indexes,and reduce the number and incidence of colds,which has good short-term and longterm effects,and achieves a certain preventive effect.