Abstract： Objective： To observe the clinical effect of modified Linggui Zhugan Decoction combined with Guifu Dihuang Pills on vertigo with spleen- kidney yang deficiency syndrome due to insufficiency of cerebral arterial blood supply. Methods： A total of 102 patients with vertigo with spleen- kidney yang deficiency syndrome due to insufficiency of cerebral arterial blood supply were selected and divided into the observation group and the control group according to the random number table method，with 51 cases in each group. The control group was given Flunarizine Hydrochloride Capsules for treatment， and the observation group was additionally treated with modified Linggui Zhugan Decoction combined with Guifu Dihuang Pills based on the treatment of the control group. Both groups were treated for 4 weeks. The clinical effects， traditional Chinese medicine(TCM) syndrome scores， scores of European Evaluation of Vertigo (EEV) and Dizziness Handicap Inventory (DHI)，indexes of cerebral blood flow，and levels of serum thromboxane B2 (TXB2) and interleukin- 6 (IL-6) were compared between the two groups. Results：After treatment， the total clinical effective rate was 92.16% in the observation group， higher than that of 76.47% in the control group (P＜0.05). The scores of primary and secondary symptoms as well as the total scores of TCM syndrome in both groups were decreased when compared with those before treatment (P＜ 0.05)，and the above three scores in the observation group were lower than those in the control group (P＜ 0.05). The scores of EEV and DHI in the two groups were decreased when compared with those before treatment (P＜0.05)， and the above two scores in the observation group were lower than those in the control group (P＜0.05). The systolic velocity (Vs)， diastolic velocity (Vd)， and mean velocity (Vm) of bilateral vertebral and basilar arteries in both groups were increased when compared with those before treatment (P＜0.05)，and the average cerebral blood flow was increased when compared with that before treatment (P＜0.05)；the Vs，Vd，and Vm of bilateral vertebral and basilar arteries in the observation group were higher than those in the control group (P＜0.05)，and the average cerebral blood flow was larger than that in the control group (P＜0.05). The levels of serum TXB2 and IL- 6 in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above two levels in the observation group were lower than those in the control group (P＜0.05). Conclusion： Modified Linggui Zhugan Decoction combined with Guifu Dihuang Pills for vertigo with spleen- kidney yang deficiency syndrome due to insufficiency of cerebral arterial blood supply can effectively mitigate the vertigo of patients， improve the indexes of cerebral blood flow，and reduce the levels of serum TXB2 and IL-6.