Abstract：Objective：To observe the clinical effect of method of nourishing yin，tonifying blood and unblocking the collaterals combined with routine western medicine on gouty nephropathy. Methods：A total of 106 patients with gouty nephropathy were selected and divided into the study group and the control group according to the random number table method，with 53 cases in each group. The control group was given routine western medicine for treatment，and the study group was additionally treated with method of nourishing yin，tonifying blood and unblocking the collaterals based on the treatment of the control group. Before and after treatment，the levels of serum soluble intracellular adhesion molecule- 1 (sVCAM- 1)， monocyte chemoattractant protein-1 (MCP-1)，nuclear factor κB (NF-κB)，NACHT-LRR-PYD domain protein 3 (NALP3)， von Willebrand Factor (vWF)， vascular endothelial growth factor (VEGF)， reactive oxygen species (ROS)，superoxide dismutase (SOD)，total antioxidant capacity (TAOC) and urine acid (UA) were compared between the two groups；the levels of α1-microglobulin (α1-MG) ，β-D galactosidases (GAL)，N-acetyl-β-D-glucosidase (NAG) and alanine aminopeptidase (AAP) in urine in the two groups were detected；the minimum end-diastolic velocity (Vdmin)，maximum systolic velocity (Vsmax)，and resistance index (RI) of the middle renal aorta in both groups were detected，and the clinical effects were evaluated. Results：After treatment，the levels of serum NF-κB，NALP3，MCP-1，UA，ROS，vWF and sICAM-1 in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above seven levels in the study group were lower than those in the control group (P＜0.05). After treatment，the levels of serum SOD，TAOC and VEGF in both groups were increased when compared with those before treatment (P＜0.05)，and the above three levels in the study group were higher than those in the control group (P＜0.05). After treatment，the levels of α1-MG，GAL，NAG and AAP in urine in the two groups were decreased when compared with those before treatment (P＜0.05)，and the above four levels in the study group were lower than those in the control group (P＜0.05). After treatment，the Vdmin and Vsmax of the middle renal aorta in both groups were increased when compared with those before treatment (P＜0.05)，and the above two items in the study group were higher than those in the control group (P＜ 0.05)；the RI of the middle renal aorta in the two groups was decreased when compared with that before treatment (P＜0.05)，and the RI in the study group was lower than that in the control group (P＜0.05). The total effective rate was 96.23% in the study group，higher than that of 84.91% in the control group (P＜ 0.05). Conclusion：The method of nourishing yin，tonifying blood and unblocking the collaterals combined with routine western medicine for patients with gouty nephropathy can inhibit the microinflammation state of the body，reduce the oxidative stress，enhance the vascular endothelial function，reduce the renal tubular injury，improve the renal hemodynamics and increase the clinical effect.