Abstract：Objective：To observe the clinical effect of constipation-relieving and zang-fu organs tuina on the improvement of shift work disorder (SWD) in male patients. Methods：A total of 50 male SWD patients were selected and divided into the treatment group and the control group according to random number table method，with 25 cases in each group. A total of 13 cases fell off due to force majeure factors such as post transfer，and finally，20 cases were included in the treatment group and 17 cases in the control group. The control group was treated with sleep behavior therapy，and the treatment group was additionally treated with constipation-relieving and zang-fu organs tuina based on the treatment of the control group. Both groups were treated for 4 weeks. The scores of Pittsburgh Sleep Quality Index (PSQI) and Flinders Fatigue Scale (FFS) before and after treatment as well as the clinical effects were compared between the two groups. Results：After treatment，the PSQI and FFS scores in the two groups were decreased when compared with those before treatment (P＜0.05)，the FFS score in the treatment group was lower than that in the control group(P＜0.05). There was no significant difference in the comparison of PSQI score between the two groups (P＞0.05). The total effective rate of clinical effect was 65.00% in the treatment group and 58.82% in the control group，there being no significance in the difference (P＞0.05). Conclusion：Constipation-relieving and zang-fu organs tuina can reduce the fatigue degree of male SWD patients，but its effectiveness in sleep quality remains to be further discussed.